Next generation plasma proteome profiling to monitor health and disease
The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22767-z |
| _version_ | 1819126457890242560 |
|---|---|
| author | Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén |
| author_facet | Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén |
| author_sort | Wen Zhong |
| collection | DOAJ |
| description | The proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma. |
| first_indexed | 2024-12-22T07:56:21Z |
| format | Article |
| id | doaj.art-1bbb3cacc2fd454eb90474d2d27c313f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:56:21Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1bbb3cacc2fd454eb90474d2d27c313f2022-12-21T18:33:21ZengNature PortfolioNature Communications2041-17232021-05-0112111210.1038/s41467-021-22767-zNext generation plasma proteome profiling to monitor health and diseaseWen Zhong0Fredrik Edfors1Anders Gummesson2Göran Bergström3Linn Fagerberg4Mathias Uhlén5Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of TechnologyScience for Life Laboratory, Department of Protein Science, KTH-Royal Institute of TechnologyDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg UniversityDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg UniversityScience for Life Laboratory, Department of Protein Science, KTH-Royal Institute of TechnologyScience for Life Laboratory, Department of Protein Science, KTH-Royal Institute of TechnologyThe proximity extension assay (PEA) is a popular tool to measure plasma protein levels. Here, the authors extend the proteome coverage of PEA by combining it with next-generation sequencing, enabling the analysis of nearly 1500 proteins from minute amounts of plasma.https://doi.org/10.1038/s41467-021-22767-z |
| spellingShingle | Wen Zhong Fredrik Edfors Anders Gummesson Göran Bergström Linn Fagerberg Mathias Uhlén Next generation plasma proteome profiling to monitor health and disease Nature Communications |
| title | Next generation plasma proteome profiling to monitor health and disease |
| title_full | Next generation plasma proteome profiling to monitor health and disease |
| title_fullStr | Next generation plasma proteome profiling to monitor health and disease |
| title_full_unstemmed | Next generation plasma proteome profiling to monitor health and disease |
| title_short | Next generation plasma proteome profiling to monitor health and disease |
| title_sort | next generation plasma proteome profiling to monitor health and disease |
| url | https://doi.org/10.1038/s41467-021-22767-z |
| work_keys_str_mv | AT wenzhong nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT fredrikedfors nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT andersgummesson nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT goranbergstrom nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT linnfagerberg nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease AT mathiasuhlen nextgenerationplasmaproteomeprofilingtomonitorhealthanddisease |