<i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens
Frankincense (<i>Boswellia sacra</i> oleo gum resin) is reported to possess antimicrobial activity against several pathogens in-vitro. The antimicrobial effects of frankincense oil and its interaction with imipenem and gentamicin against methicillin-resistant <i>Staphylococcus aure...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1591 |
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| author | Megren Bin Faisal Almutairi Mohammed Alrouji Yasir Almuhanna Mohammed Asad Babu Joseph |
| author_facet | Megren Bin Faisal Almutairi Mohammed Alrouji Yasir Almuhanna Mohammed Asad Babu Joseph |
| author_sort | Megren Bin Faisal Almutairi |
| collection | DOAJ |
| description | Frankincense (<i>Boswellia sacra</i> oleo gum resin) is reported to possess antimicrobial activity against several pathogens in-vitro. The antimicrobial effects of frankincense oil and its interaction with imipenem and gentamicin against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and multidrug-resistant <i>P. aeruginosa</i> were determined through in-vitro methods and an in-vivo study using a rat pneumonia model. Frankincense oil was subjected to GC-MS analysis to determine the different volatile components. Antibacterial effects against MRSA and MDR-<i>P. aeruginosa</i> was evaluated and its MIC and MBC were determined. For the rat pneumonia model (in-vivo), oil was administered at a dose of 500 mg/kg and 1000 mg/kg followed by determination of CFU in lung tissue and histological studies. Frankincense oil did not show a very potent inhibitory effect against MRSA or MDR-<i>P. aeruginosa</i>; the oil did not affect the zone of inhibition or FIC when combined with imipenem or gentamicin indicating a lack of interaction between the oil and the antibiotics. Furthermore, there was no interaction between the antibiotics and the frankincense oil in the in-vivo model. The result of the study revealed that frankincense oil has a weak inhibitory effect against MRSA and MDR-<i>P. aeruginosa</i>, and it did not show any interaction with imipenem or gentamicin. |
| first_indexed | 2024-03-09T19:18:47Z |
| format | Article |
| id | doaj.art-1bbb4c5be8504aa8b6de2241584cc6b6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T19:18:47Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1bbb4c5be8504aa8b6de2241584cc6b62023-11-24T03:28:53ZengMDPI AGAntibiotics2079-63822022-11-011111159110.3390/antibiotics11111591<i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant PathogensMegren Bin Faisal Almutairi0Mohammed Alrouji1Yasir Almuhanna2Mohammed Asad3Babu Joseph4Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaFrankincense (<i>Boswellia sacra</i> oleo gum resin) is reported to possess antimicrobial activity against several pathogens in-vitro. The antimicrobial effects of frankincense oil and its interaction with imipenem and gentamicin against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and multidrug-resistant <i>P. aeruginosa</i> were determined through in-vitro methods and an in-vivo study using a rat pneumonia model. Frankincense oil was subjected to GC-MS analysis to determine the different volatile components. Antibacterial effects against MRSA and MDR-<i>P. aeruginosa</i> was evaluated and its MIC and MBC were determined. For the rat pneumonia model (in-vivo), oil was administered at a dose of 500 mg/kg and 1000 mg/kg followed by determination of CFU in lung tissue and histological studies. Frankincense oil did not show a very potent inhibitory effect against MRSA or MDR-<i>P. aeruginosa</i>; the oil did not affect the zone of inhibition or FIC when combined with imipenem or gentamicin indicating a lack of interaction between the oil and the antibiotics. Furthermore, there was no interaction between the antibiotics and the frankincense oil in the in-vivo model. The result of the study revealed that frankincense oil has a weak inhibitory effect against MRSA and MDR-<i>P. aeruginosa</i>, and it did not show any interaction with imipenem or gentamicin.https://www.mdpi.com/2079-6382/11/11/1591pneumoniavolatile oils<i>Boswellia</i>MICMBC |
| spellingShingle | Megren Bin Faisal Almutairi Mohammed Alrouji Yasir Almuhanna Mohammed Asad Babu Joseph <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens Antibiotics pneumonia volatile oils <i>Boswellia</i> MIC MBC |
| title | <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens |
| title_full | <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens |
| title_fullStr | <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens |
| title_full_unstemmed | <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens |
| title_short | <i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens |
| title_sort | i in vitro i and i in vivo i antibacterial effects of frankincense oil and its interaction with some antibiotics against multidrug resistant pathogens |
| topic | pneumonia volatile oils <i>Boswellia</i> MIC MBC |
| url | https://www.mdpi.com/2079-6382/11/11/1591 |
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