Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients
Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) l...
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| Format: | Article |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00217/full |
| _version_ | 1818217624386928640 |
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| author | Yong Liu Yong Liu Yong Liu Huai Tao Xiudeng Yang Kai Huang Kai Huang Kai Huang Xianghui Zhang Xianghui Zhang Xianghui Zhang Cunyan Li |
| author_facet | Yong Liu Yong Liu Yong Liu Huai Tao Xiudeng Yang Kai Huang Kai Huang Kai Huang Xianghui Zhang Xianghui Zhang Xianghui Zhang Cunyan Li |
| author_sort | Yong Liu |
| collection | DOAJ |
| description | Schizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in 52 first-episode schizophrenia (FES) patients and 41 healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were significantly lower in FES patients (518.96 ± 22.22 and 174.60 ± 17.11 pg/ml) than the HC group (711.58 ± 40.57 and 252.15 ± 20.62 pg/ml). Serum IL-6 and hsCRP levels showed no difference between the two groups (1.82 ± 0.30 vs. 1.69 ± 0.36 pg/ml, 0.66 (0.22, 1.07) vs. 0.31 (0.13, 0.91) mg/L), but serum Hcy levels were significantly higher in FES patients (20.18 ± 1.83 vs. 15.24 ± 0.82 μmol/ml). The FES patients (0.27 ± 0.02 and 0.20 ± 0.02) have relatively higher mRNA expressions of OXT and OXTR genes than the HC group (0.16 ± 0.01 and 0.14 ± 0.01). In summary, our results suggested the possible function of the OXT system and Hcy in the pathogenesis of SZ. |
| first_indexed | 2024-12-12T07:10:49Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T07:10:49Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-1bbb688467194f8ebcdfc490700d38bd2022-12-22T00:33:38ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-04-011010.3389/fpsyt.2019.00217434722Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia PatientsYong Liu0Yong Liu1Yong Liu2Huai Tao3Xiudeng Yang4Kai Huang5Kai Huang6Kai Huang7Xianghui Zhang8Xianghui Zhang9Xianghui Zhang10Cunyan Li11Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya) and China National Technology Institute on Mental Disorders, Changsha, ChinaMental Health Institute of Central South University and Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Biochemistry and Molecular Biology, Hunan University of Chinese Medicine, Changsha, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Shaoyang University, Shaoyang, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya) and China National Technology Institute on Mental Disorders, Changsha, ChinaMental Health Institute of Central South University and Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya) and China National Technology Institute on Mental Disorders, Changsha, ChinaMental Health Institute of Central South University and Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaDepartment of Laboratory Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaSchizophrenia (SZ) is a debilitating and heterogeneous disease. We hypothesized that the oxytocin (OXT) system, inflammation and one-carbon metabolism would have a link with SZ. In this study, serum OXT, OXT receptor (OXTR), interleukin-6 (IL-6), high sensitivity CRP (hsCRP) and homocysteine (Hcy) levels were measured in 52 first-episode schizophrenia (FES) patients and 41 healthy controls (HC) from the Second Xiangya Hospital of Central South University. Meanwhile, the mRNA expressions of OXT and OXTR genes were determined by real-time quantitative PCR. Serum OXT and OXTR levels were significantly lower in FES patients (518.96 ± 22.22 and 174.60 ± 17.11 pg/ml) than the HC group (711.58 ± 40.57 and 252.15 ± 20.62 pg/ml). Serum IL-6 and hsCRP levels showed no difference between the two groups (1.82 ± 0.30 vs. 1.69 ± 0.36 pg/ml, 0.66 (0.22, 1.07) vs. 0.31 (0.13, 0.91) mg/L), but serum Hcy levels were significantly higher in FES patients (20.18 ± 1.83 vs. 15.24 ± 0.82 μmol/ml). The FES patients (0.27 ± 0.02 and 0.20 ± 0.02) have relatively higher mRNA expressions of OXT and OXTR genes than the HC group (0.16 ± 0.01 and 0.14 ± 0.01). In summary, our results suggested the possible function of the OXT system and Hcy in the pathogenesis of SZ.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00217/fullFESOXTOXTRIL-6hsCRPHcy |
| spellingShingle | Yong Liu Yong Liu Yong Liu Huai Tao Xiudeng Yang Kai Huang Kai Huang Kai Huang Xianghui Zhang Xianghui Zhang Xianghui Zhang Cunyan Li Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients Frontiers in Psychiatry FES OXT OXTR IL-6 hsCRP Hcy |
| title | Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients |
| title_full | Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients |
| title_fullStr | Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients |
| title_full_unstemmed | Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients |
| title_short | Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients |
| title_sort | decreased serum oxytocin and increased homocysteine in first episode schizophrenia patients |
| topic | FES OXT OXTR IL-6 hsCRP Hcy |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00217/full |
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