Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer

Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer

Off-target effects of drugs severely limit cancer therapy. Targeted nanocarriers are promising to enhance the delivery of therapeutics to tumors. Among many approaches for active tumor-targeting, arginine-rich cell penetrating peptides (AR-CPP) and ligands specific to target over-expressed receptors...

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Bibliographic Details
Main Authors: Pranali Deshpande, Aditi Jhaveri, Bhushan Pattni, Swati Biswas, Vladimir Torchilin
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
liposomes
transferrin
doxorubicin
octaarginine
active targeting
ovarian cancer
tfr over-expression
dual-functional liposomes
Online Access:http://dx.doi.org/10.1080/10717544.2018.1435747

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