Rat model of asphyxia-induced cardiac arrest and resuscitation
Neurologic injury after cardiopulmonary resuscitation is the main cause of the low survival rate and poor quality of life among patients who have experienced cardiac arrest. In the United States, as the American Heart Association reported, emergency medical services respond to more than 347,000 adul...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1087725/full |
| _version_ | 1797961358144176128 |
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| author | Shuhang Yu Chenghao Wu Ying Zhu Mengyuan Diao Wei Hu |
| author_facet | Shuhang Yu Chenghao Wu Ying Zhu Mengyuan Diao Wei Hu |
| author_sort | Shuhang Yu |
| collection | DOAJ |
| description | Neurologic injury after cardiopulmonary resuscitation is the main cause of the low survival rate and poor quality of life among patients who have experienced cardiac arrest. In the United States, as the American Heart Association reported, emergency medical services respond to more than 347,000 adults and more than 7,000 children with out-of-hospital cardiac arrest each year. In-hospital cardiac arrest is estimated to occur in 9.7 per 1,000 adult cardiac arrests and 2.7 pediatric events per 1,000 hospitalizations. Yet the pathophysiological mechanisms of this injury remain unclear. Experimental animal models are valuable for exploring the etiologies and mechanisms of diseases and their interventions. In this review, we summarize how to establish a standardized rat model of asphyxia-induced cardiac arrest. There are four key focal areas: (1) selection of animal species; (2) factors to consider during modeling; (3) intervention management after return of spontaneous circulation; and (4) evaluation of neurologic function. The aim was to simplify a complex animal model, toward clarifying cardiac arrest pathophysiological processes. It also aimed to help standardize model establishment, toward facilitating experiment homogenization, convenient interexperimental comparisons, and translation of experimental results to clinical application. |
| first_indexed | 2024-04-11T00:57:19Z |
| format | Article |
| id | doaj.art-1bbd0290928b496d9497570317fed32e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T00:57:19Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-1bbd0290928b496d9497570317fed32e2023-01-04T23:10:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-01-011610.3389/fnins.2022.10877251087725Rat model of asphyxia-induced cardiac arrest and resuscitationShuhang YuChenghao WuYing ZhuMengyuan DiaoWei HuNeurologic injury after cardiopulmonary resuscitation is the main cause of the low survival rate and poor quality of life among patients who have experienced cardiac arrest. In the United States, as the American Heart Association reported, emergency medical services respond to more than 347,000 adults and more than 7,000 children with out-of-hospital cardiac arrest each year. In-hospital cardiac arrest is estimated to occur in 9.7 per 1,000 adult cardiac arrests and 2.7 pediatric events per 1,000 hospitalizations. Yet the pathophysiological mechanisms of this injury remain unclear. Experimental animal models are valuable for exploring the etiologies and mechanisms of diseases and their interventions. In this review, we summarize how to establish a standardized rat model of asphyxia-induced cardiac arrest. There are four key focal areas: (1) selection of animal species; (2) factors to consider during modeling; (3) intervention management after return of spontaneous circulation; and (4) evaluation of neurologic function. The aim was to simplify a complex animal model, toward clarifying cardiac arrest pathophysiological processes. It also aimed to help standardize model establishment, toward facilitating experiment homogenization, convenient interexperimental comparisons, and translation of experimental results to clinical application.https://www.frontiersin.org/articles/10.3389/fnins.2022.1087725/fullcardiac arrestasphyxiaexperimental animal modelsratneurological deficit |
| spellingShingle | Shuhang Yu Chenghao Wu Ying Zhu Mengyuan Diao Wei Hu Rat model of asphyxia-induced cardiac arrest and resuscitation Frontiers in Neuroscience cardiac arrest asphyxia experimental animal models rat neurological deficit |
| title | Rat model of asphyxia-induced cardiac arrest and resuscitation |
| title_full | Rat model of asphyxia-induced cardiac arrest and resuscitation |
| title_fullStr | Rat model of asphyxia-induced cardiac arrest and resuscitation |
| title_full_unstemmed | Rat model of asphyxia-induced cardiac arrest and resuscitation |
| title_short | Rat model of asphyxia-induced cardiac arrest and resuscitation |
| title_sort | rat model of asphyxia induced cardiac arrest and resuscitation |
| topic | cardiac arrest asphyxia experimental animal models rat neurological deficit |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1087725/full |
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