Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride
The extraordinary features of cerium oxide (CeO2) and zinc oxide (ZnO) nanostructures have encouraged substantial attention to those nanocomposites as probable electroactive complexes for sensing and biosensing purposes. In this study, an advanced novel factionalized CeO2/ZnO nanocomposite-aluminum...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023030001 |
| _version_ | 1827937431035314176 |
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| author | Suliman Y. Al Omar Amal M. Al-Mohaimeed Maha F. El-Tohamy |
| author_facet | Suliman Y. Al Omar Amal M. Al-Mohaimeed Maha F. El-Tohamy |
| author_sort | Suliman Y. Al Omar |
| collection | DOAJ |
| description | The extraordinary features of cerium oxide (CeO2) and zinc oxide (ZnO) nanostructures have encouraged substantial attention to those nanocomposites as probable electroactive complexes for sensing and biosensing purposes. In this study, an advanced novel factionalized CeO2/ZnO nanocomposite-aluminum wire membrane sensor was designed to assess pethidine hydrochloride (PTD) in commercial injection samples. Pethidine-reineckate (PTD-RK) was formed by mixing pethidine hydrochloride and ammonium reineckate (ARK) in the presence of polymeric matrix (polyvinyl chloride) and o-nitrophenyl octyl ether as a fluidizing agent. The functionalized nanocomposite sensor displayed a fast dynamic response and wide linearity for the detection of PTD. It also revealed excellent selectivity and sensitivity, high accuracy, and precision for the determination and quantification of PTD when compared with the unmodified sensor PTD-RK. The guidelines of analytical methodology requirements were obeyed to improve the suitability and validity of the suggested potentiometric system according to several criteria. The developed potentiometric system was suitable for the determination of PTD in bulk powder and commercial products. |
| first_indexed | 2024-03-13T08:25:31Z |
| format | Article |
| id | doaj.art-1bbd57e68c494a9c9b1b826c1b826705 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:31Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1bbd57e68c494a9c9b1b826c1b8267052023-05-31T04:45:34ZengElsevierHeliyon2405-84402023-05-0195e15793Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochlorideSuliman Y. Al Omar0Amal M. Al-Mohaimeed1Maha F. El-Tohamy2Doping Research Chair, Zoology Department, College of Science, King Saud University, Riyadh University, Riyadh-11451, Kingdom of Saudi Arabia; Corresponding author.Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia; Corresponding author.The extraordinary features of cerium oxide (CeO2) and zinc oxide (ZnO) nanostructures have encouraged substantial attention to those nanocomposites as probable electroactive complexes for sensing and biosensing purposes. In this study, an advanced novel factionalized CeO2/ZnO nanocomposite-aluminum wire membrane sensor was designed to assess pethidine hydrochloride (PTD) in commercial injection samples. Pethidine-reineckate (PTD-RK) was formed by mixing pethidine hydrochloride and ammonium reineckate (ARK) in the presence of polymeric matrix (polyvinyl chloride) and o-nitrophenyl octyl ether as a fluidizing agent. The functionalized nanocomposite sensor displayed a fast dynamic response and wide linearity for the detection of PTD. It also revealed excellent selectivity and sensitivity, high accuracy, and precision for the determination and quantification of PTD when compared with the unmodified sensor PTD-RK. The guidelines of analytical methodology requirements were obeyed to improve the suitability and validity of the suggested potentiometric system according to several criteria. The developed potentiometric system was suitable for the determination of PTD in bulk powder and commercial products.http://www.sciencedirect.com/science/article/pii/S2405844023030001Pethidine hydrochloridePotentiometric sensorsMetal oxidesNanocompositePolymeric sensorsPharmaceuticals |
| spellingShingle | Suliman Y. Al Omar Amal M. Al-Mohaimeed Maha F. El-Tohamy Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride Heliyon Pethidine hydrochloride Potentiometric sensors Metal oxides Nanocomposite Polymeric sensors Pharmaceuticals |
| title | Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| title_full | Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| title_fullStr | Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| title_full_unstemmed | Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| title_short | Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| title_sort | ultrasensitive functionalized ceo2 zno nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride |
| topic | Pethidine hydrochloride Potentiometric sensors Metal oxides Nanocomposite Polymeric sensors Pharmaceuticals |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023030001 |
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