The effect of metformin on vitamin B12 level in pediatric patients
Purpose Metformin is a common medication for patients with hyperglycemia. In adults, one well-documented side effect of metformin is vitamin B12 deficiency. However, this side effect has rarely been studied in pediatric patients. This study examined the changes of vitamin B12 level in pediatric pati...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pediatric Endocrinology
2022-05-01
|
| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-2142210-105.pdf |
| _version_ | 1797996472391696384 |
|---|---|
| author | Y. Miles Yu Simon K.C. So Bertha Ben Khallouq |
| author_facet | Y. Miles Yu Simon K.C. So Bertha Ben Khallouq |
| author_sort | Y. Miles Yu |
| collection | DOAJ |
| description | Purpose Metformin is a common medication for patients with hyperglycemia. In adults, one well-documented side effect of metformin is vitamin B12 deficiency. However, this side effect has rarely been studied in pediatric patients. This study examined the changes of vitamin B12 level in pediatric patients being treated with metformin. Methods Data were collected from pediatric patients (n=151) with at least 3 months of consecutive metformin intake. The effects of dose of metformin on the mean vitamin B12 level were investigated at 6, 12, 24, and 36 months. The effect of compliance of metformin intake on vitamin B12 level also was studied. Results There was no significant decrease in mean vitamin B12 level at 6, 12, 24, or 36 months in patients treated with metformin. Mean vitamin B12 decrease was only noticeable (P<0.05) in patients taking a high dose of metformin with good compliance. Despite this change, the mean vitamin B12 remained well within the normal reference range. Furthermore, of the 151 patients studied, only 1 demonstrated vitamin B12 deficiency after 12 months of treatment. However, his B12 level was normal at 24 and 36 months without any vitamin B12 supplements. Conclusions Our findings suggest that metformin treatment in children does not cause vitamin B12 deficiency; however, the effect of long-term consistent high-dose treatment on vitamin B12 level remains unknown. |
| first_indexed | 2024-04-11T10:16:55Z |
| format | Article |
| id | doaj.art-1bbe09077f444acabd1bfe1923a6a3d0 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-04-11T10:16:55Z |
| publishDate | 2022-05-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-1bbe09077f444acabd1bfe1923a6a3d02022-12-22T04:29:54ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922022-05-0127322322810.6065/apem.2142210.105930The effect of metformin on vitamin B12 level in pediatric patientsY. Miles Yu0Simon K.C. So1Bertha Ben Khallouq2 Pediatric Endocrinology, Nemours Children’s Hospital, Orlando, FL, USA Synergy Health Primary Care Clinic, Irvine, CA, USA University of Central Florida College of Science, Orlando, FL, USAPurpose Metformin is a common medication for patients with hyperglycemia. In adults, one well-documented side effect of metformin is vitamin B12 deficiency. However, this side effect has rarely been studied in pediatric patients. This study examined the changes of vitamin B12 level in pediatric patients being treated with metformin. Methods Data were collected from pediatric patients (n=151) with at least 3 months of consecutive metformin intake. The effects of dose of metformin on the mean vitamin B12 level were investigated at 6, 12, 24, and 36 months. The effect of compliance of metformin intake on vitamin B12 level also was studied. Results There was no significant decrease in mean vitamin B12 level at 6, 12, 24, or 36 months in patients treated with metformin. Mean vitamin B12 decrease was only noticeable (P<0.05) in patients taking a high dose of metformin with good compliance. Despite this change, the mean vitamin B12 remained well within the normal reference range. Furthermore, of the 151 patients studied, only 1 demonstrated vitamin B12 deficiency after 12 months of treatment. However, his B12 level was normal at 24 and 36 months without any vitamin B12 supplements. Conclusions Our findings suggest that metformin treatment in children does not cause vitamin B12 deficiency; however, the effect of long-term consistent high-dose treatment on vitamin B12 level remains unknown.http://e-apem.org/upload/pdf/apem-2142210-105.pdfmetforminvitamin b12antiglycemicdoseduration |
| spellingShingle | Y. Miles Yu Simon K.C. So Bertha Ben Khallouq The effect of metformin on vitamin B12 level in pediatric patients Annals of Pediatric Endocrinology & Metabolism metformin vitamin b12 antiglycemic dose duration |
| title | The effect of metformin on vitamin B12 level in pediatric patients |
| title_full | The effect of metformin on vitamin B12 level in pediatric patients |
| title_fullStr | The effect of metformin on vitamin B12 level in pediatric patients |
| title_full_unstemmed | The effect of metformin on vitamin B12 level in pediatric patients |
| title_short | The effect of metformin on vitamin B12 level in pediatric patients |
| title_sort | effect of metformin on vitamin b12 level in pediatric patients |
| topic | metformin vitamin b12 antiglycemic dose duration |
| url | http://e-apem.org/upload/pdf/apem-2142210-105.pdf |
| work_keys_str_mv | AT ymilesyu theeffectofmetforminonvitaminb12levelinpediatricpatients AT simonkcso theeffectofmetforminonvitaminb12levelinpediatricpatients AT berthabenkhallouq theeffectofmetforminonvitaminb12levelinpediatricpatients AT ymilesyu effectofmetforminonvitaminb12levelinpediatricpatients AT simonkcso effectofmetforminonvitaminb12levelinpediatricpatients AT berthabenkhallouq effectofmetforminonvitaminb12levelinpediatricpatients |