How the extracellular matrix shapes neural development
During development, both cells and tissues must acquire the correct shape to allow their proper function. This is especially relevant in the nervous system, where the shape of individual cell processes, such as the axons and dendrites, and the shape of entire tissues, such as the folding of the neoc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2019-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180216 |
| _version_ | 1818444448881704960 |
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| author | Katherine R. Long Wieland B. Huttner |
| author_facet | Katherine R. Long Wieland B. Huttner |
| author_sort | Katherine R. Long |
| collection | DOAJ |
| description | During development, both cells and tissues must acquire the correct shape to allow their proper function. This is especially relevant in the nervous system, where the shape of individual cell processes, such as the axons and dendrites, and the shape of entire tissues, such as the folding of the neocortex, are highly specialized. While many aspects of neural development have been uncovered, there are still several open questions concerning the mechanisms governing cell and tissue shape. In this review, we discuss the role of the extracellular matrix (ECM) in these processes. In particular, we consider how the ECM regulates cell shape, proliferation, differentiation and migration, and more recent work highlighting a key role of ECM in the morphogenesis of neural tissues. |
| first_indexed | 2024-12-14T19:16:06Z |
| format | Article |
| id | doaj.art-1bc187ecda974d4e91226b2f146430b5 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-14T19:16:06Z |
| publishDate | 2019-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-1bc187ecda974d4e91226b2f146430b52022-12-21T22:50:35ZengThe Royal SocietyOpen Biology2046-24412019-01-019110.1098/rsob.180216180216How the extracellular matrix shapes neural developmentKatherine R. LongWieland B. HuttnerDuring development, both cells and tissues must acquire the correct shape to allow their proper function. This is especially relevant in the nervous system, where the shape of individual cell processes, such as the axons and dendrites, and the shape of entire tissues, such as the folding of the neocortex, are highly specialized. While many aspects of neural development have been uncovered, there are still several open questions concerning the mechanisms governing cell and tissue shape. In this review, we discuss the role of the extracellular matrix (ECM) in these processes. In particular, we consider how the ECM regulates cell shape, proliferation, differentiation and migration, and more recent work highlighting a key role of ECM in the morphogenesis of neural tissues.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180216extracellular matrixdevelopmenttissue shape |
| spellingShingle | Katherine R. Long Wieland B. Huttner How the extracellular matrix shapes neural development Open Biology extracellular matrix development tissue shape |
| title | How the extracellular matrix shapes neural development |
| title_full | How the extracellular matrix shapes neural development |
| title_fullStr | How the extracellular matrix shapes neural development |
| title_full_unstemmed | How the extracellular matrix shapes neural development |
| title_short | How the extracellular matrix shapes neural development |
| title_sort | how the extracellular matrix shapes neural development |
| topic | extracellular matrix development tissue shape |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180216 |
| work_keys_str_mv | AT katherinerlong howtheextracellularmatrixshapesneuraldevelopment AT wielandbhuttner howtheextracellularmatrixshapesneuraldevelopment |