Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study
Jiefeng Huang,1– 3,* Lida Chen,4,* Xiuling Li,1– 3,* Menglan Chen,1– 3 Ting Lin,1– 3 Gongping Chen1– 3 1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou, People’s Republic of Ch...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/association-between-metabolic-associated-fatty-liver-disease-and-obstr-peer-reviewed-fulltext-article-NSS |
| _version_ | 1811162853194858496 |
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| author | Huang J Chen L Li X Chen M Lin T Chen G |
| author_facet | Huang J Chen L Li X Chen M Lin T Chen G |
| author_sort | Huang J |
| collection | DOAJ |
| description | Jiefeng Huang,1– 3,* Lida Chen,4,* Xiuling Li,1– 3,* Menglan Chen,1– 3 Ting Lin,1– 3 Gongping Chen1– 3 1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou, People’s Republic of China; 2Institute of Respiratory Disease, Fujian Medical University, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Xiangcheng, Zhangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gongping Chen, Tel/Fax +86591-87981697, Email cgp2389@126.comAim: Emerging evidence has revealed that obstructive sleep apnea (OSA) is an independent risk factor for the development of a variety of adverse metabolic disease states. In this study, we evaluated the association between OSA severity and metabolic dysfunction-associated fatty liver disease (MAFLD) among Asian populations.Materials and Methods: This was a cross-sectional, single-center study. The study cohort consisted of patients undergoing polysomnography and abdominal ultrasonography. Logistic regression analysis was used to evaluate the independent risk factors of MAFLD in patients with OSA.Results: A total of 1065 patients (277 non-MAFLD and 788 MAFLD) were included in the study. The prevalence of MAFLD in non-OSA, mild-moderate OSA, and severe OSA patients was 58.16%, 72.41%, and 78.0%, respectively (p < 0.001). We identified significant differences in body mass index (BMI), apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and lowest O2 saturation (LaSO2) between non-MAFLD and MAFLD patients (all p < 0.001). After adjusting for confounding variables, we used multivariate regression analysis to show that BMI, ODI, and triglyceride (TG) levels independently predicted the occurrence of MAFLD (odds ratio [OR] = 1.234, p < 0.001; OR = 1.022, p = 0.013; OR = 1.384, p = 0.001, respectively). Moreover, stratified analysis according to BMI indicated that TG levels were the predominant risk factor for MAFLD in a group of patients with a BMI < 23 kg/m2, while BMI, ODI, TG levels, and total cholesterol (TC) were the major risk factors for MAFLD in a group of patients with a BMI ≥ 23 kg/m2 (all p < 0.05).Conclusion: OSA-associated chronic intermittent hypoxia was independently associated with the risk of MAFLD, especially in OSA patients with a BMI ≥ 23 kg/m2, suggesting that oxidative stress might play an important role in the pathogenesis of MAFLD in patients with OSA.Keywords: obstructive sleep apnea, chronic intermittent hypoxia, metabolic dysfunction-associated fatty liver disease, obesity |
| first_indexed | 2024-04-10T06:37:02Z |
| format | Article |
| id | doaj.art-1bc1a956a7cf4c73ac619d19109b779e |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-04-10T06:37:02Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-1bc1a956a7cf4c73ac619d19109b779e2023-02-28T18:02:44ZengDove Medical PressNature and Science of Sleep1179-16082023-02-01Volume 15495781935Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional StudyHuang JChen LLi XChen MLin TChen GJiefeng Huang,1– 3,* Lida Chen,4,* Xiuling Li,1– 3,* Menglan Chen,1– 3 Ting Lin,1– 3 Gongping Chen1– 3 1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou, People’s Republic of China; 2Institute of Respiratory Disease, Fujian Medical University, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Xiangcheng, Zhangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gongping Chen, Tel/Fax +86591-87981697, Email cgp2389@126.comAim: Emerging evidence has revealed that obstructive sleep apnea (OSA) is an independent risk factor for the development of a variety of adverse metabolic disease states. In this study, we evaluated the association between OSA severity and metabolic dysfunction-associated fatty liver disease (MAFLD) among Asian populations.Materials and Methods: This was a cross-sectional, single-center study. The study cohort consisted of patients undergoing polysomnography and abdominal ultrasonography. Logistic regression analysis was used to evaluate the independent risk factors of MAFLD in patients with OSA.Results: A total of 1065 patients (277 non-MAFLD and 788 MAFLD) were included in the study. The prevalence of MAFLD in non-OSA, mild-moderate OSA, and severe OSA patients was 58.16%, 72.41%, and 78.0%, respectively (p < 0.001). We identified significant differences in body mass index (BMI), apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and lowest O2 saturation (LaSO2) between non-MAFLD and MAFLD patients (all p < 0.001). After adjusting for confounding variables, we used multivariate regression analysis to show that BMI, ODI, and triglyceride (TG) levels independently predicted the occurrence of MAFLD (odds ratio [OR] = 1.234, p < 0.001; OR = 1.022, p = 0.013; OR = 1.384, p = 0.001, respectively). Moreover, stratified analysis according to BMI indicated that TG levels were the predominant risk factor for MAFLD in a group of patients with a BMI < 23 kg/m2, while BMI, ODI, TG levels, and total cholesterol (TC) were the major risk factors for MAFLD in a group of patients with a BMI ≥ 23 kg/m2 (all p < 0.05).Conclusion: OSA-associated chronic intermittent hypoxia was independently associated with the risk of MAFLD, especially in OSA patients with a BMI ≥ 23 kg/m2, suggesting that oxidative stress might play an important role in the pathogenesis of MAFLD in patients with OSA.Keywords: obstructive sleep apnea, chronic intermittent hypoxia, metabolic dysfunction-associated fatty liver disease, obesityhttps://www.dovepress.com/association-between-metabolic-associated-fatty-liver-disease-and-obstr-peer-reviewed-fulltext-article-NSSobstructive sleep apneachronic intermittent hypoxiametabolic dysfunction-associated fatty liver diseaseobesity |
| spellingShingle | Huang J Chen L Li X Chen M Lin T Chen G Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study Nature and Science of Sleep obstructive sleep apnea chronic intermittent hypoxia metabolic dysfunction-associated fatty liver disease obesity |
| title | Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study |
| title_full | Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study |
| title_fullStr | Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study |
| title_full_unstemmed | Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study |
| title_short | Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study |
| title_sort | association between metabolic associated fatty liver disease and obstructive sleep apnea a cross sectional study |
| topic | obstructive sleep apnea chronic intermittent hypoxia metabolic dysfunction-associated fatty liver disease obesity |
| url | https://www.dovepress.com/association-between-metabolic-associated-fatty-liver-disease-and-obstr-peer-reviewed-fulltext-article-NSS |
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