Antitumor activity of arsenite in combination with tetrandrine against human breast cancer cell line MDA-MB-231 in vitro and in vivo

Antitumor activity of arsenite in combination with tetrandrine against human breast cancer cell line MDA-MB-231 in vitro and in vivo

Abstract Background Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to its aggressive, metastatic behavior, and a lack of a targeted therapy. Trivalent arsenic derivatives (arsenite, AsIII) with remarkable clinical efficacy in acute promyelocy...

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Bibliographic Details
Main Authors: Bo Yuan, Mingjiang Yao, Xiao Wang, Ai Sato, Ayane Okazaki, Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano, Norio Takagi
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cancer Cell International
Subjects:
Arsenite
Tetrandrine
MDA-MB-231 cells
Cell death
Combination therapy
Online Access:http://link.springer.com/article/10.1186/s12935-018-0613-0

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