Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c
Abstract Oregano (Origanum vulgare) seed is used as spices and is known to have anti‐inflammatory, antibacterial, and antioxidant effects. The anti‐fatty liver effects of oregano seed ethyl acetate (OSEA) were evaluated in high‐fat diet (HFD)‐induced obese mice. OSEA was orally administered with HFD...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
|
| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.3939 |
| _version_ | 1797208902848217088 |
|---|---|
| author | Hyun‐Jong Lee Ji‐Yun Bae Kye Won Park Mi‐Ja Kim |
| author_facet | Hyun‐Jong Lee Ji‐Yun Bae Kye Won Park Mi‐Ja Kim |
| author_sort | Hyun‐Jong Lee |
| collection | DOAJ |
| description | Abstract Oregano (Origanum vulgare) seed is used as spices and is known to have anti‐inflammatory, antibacterial, and antioxidant effects. The anti‐fatty liver effects of oregano seed ethyl acetate (OSEA) were evaluated in high‐fat diet (HFD)‐induced obese mice. OSEA was orally administered with HFD for 10 weeks. The body weight, aspartate aminotransferase, alanine aminotransferase, cholesterol, triglyceride, and low‐density lipoprotein levels in the HFD with 100 mg/kg of OSEA significantly decreased by approximately 1.21‐, 1.44‐, 2.12‐, 1.12‐, 1.05, and 1.59 times, respectively, while high‐density lipoprotein levels increased by approximately 1.05 times compared to those in the HFD group (p < .05). In addition, the distribution of liver fat in the HFD with 100 mg/kg OSEA (OSEA 100) group decreased significantly (p < .05). Therefore, OSEA supplementation can ameliorate fatty liver disease and reduce the accumulation of triglycerides in adipose tissue. The expression of genes involved in liver fat accumulation, such as sterol regulatory element‐binding protein‐1c (Srebp‐1c), fatty acid synthase (Fas), stearoyl‐CoA desaturase‐1 (Scd1), and acetyl‐CoA carboxylase 1 (Acc1), significantly decreased in OSEA 100 by approximately 2.6‐, 1.74‐, 1.89‐, and 1.56‐times, respectively (p < .05). Therefore, OSEA may modify obesity and liver fat accumulation by regulating the expression of genes involved in lipid metabolism. |
| first_indexed | 2024-04-24T09:46:11Z |
| format | Article |
| id | doaj.art-1bc2894b80754c48be0e465773322b4d |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-24T09:46:11Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-1bc2894b80754c48be0e465773322b4d2024-04-15T01:06:44ZengWileyFood Science & Nutrition2048-71772024-04-011242578258710.1002/fsn3.3939Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1cHyun‐Jong Lee0Ji‐Yun Bae1Kye Won Park2Mi‐Ja Kim3Department of Food and Nutrition, College of Health Science Kangwon National University Samcheok Republic of KoreaDepartment of Food and Nutrition, College of Health Science Kangwon National University Samcheok Republic of KoreaDepartment of Food Science and Biotechnology Sungkyunkwan University Suwon Republic of KoreaDepartment of Food and Nutrition, College of Health Science Kangwon National University Samcheok Republic of KoreaAbstract Oregano (Origanum vulgare) seed is used as spices and is known to have anti‐inflammatory, antibacterial, and antioxidant effects. The anti‐fatty liver effects of oregano seed ethyl acetate (OSEA) were evaluated in high‐fat diet (HFD)‐induced obese mice. OSEA was orally administered with HFD for 10 weeks. The body weight, aspartate aminotransferase, alanine aminotransferase, cholesterol, triglyceride, and low‐density lipoprotein levels in the HFD with 100 mg/kg of OSEA significantly decreased by approximately 1.21‐, 1.44‐, 2.12‐, 1.12‐, 1.05, and 1.59 times, respectively, while high‐density lipoprotein levels increased by approximately 1.05 times compared to those in the HFD group (p < .05). In addition, the distribution of liver fat in the HFD with 100 mg/kg OSEA (OSEA 100) group decreased significantly (p < .05). Therefore, OSEA supplementation can ameliorate fatty liver disease and reduce the accumulation of triglycerides in adipose tissue. The expression of genes involved in liver fat accumulation, such as sterol regulatory element‐binding protein‐1c (Srebp‐1c), fatty acid synthase (Fas), stearoyl‐CoA desaturase‐1 (Scd1), and acetyl‐CoA carboxylase 1 (Acc1), significantly decreased in OSEA 100 by approximately 2.6‐, 1.74‐, 1.89‐, and 1.56‐times, respectively (p < .05). Therefore, OSEA may modify obesity and liver fat accumulation by regulating the expression of genes involved in lipid metabolism.https://doi.org/10.1002/fsn3.3939lipid metabolismnon‐alcoholic fatty liver diseaseobesityoreganospice |
| spellingShingle | Hyun‐Jong Lee Ji‐Yun Bae Kye Won Park Mi‐Ja Kim Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c Food Science & Nutrition lipid metabolism non‐alcoholic fatty liver disease obesity oregano spice |
| title | Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c |
| title_full | Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c |
| title_fullStr | Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c |
| title_full_unstemmed | Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c |
| title_short | Ethyl acetate fraction of oregano seed protects non‐alcoholic fatty liver in high‐fat diet‐induced obese mice through modulation of Srebp‐1c |
| title_sort | ethyl acetate fraction of oregano seed protects non alcoholic fatty liver in high fat diet induced obese mice through modulation of srebp 1c |
| topic | lipid metabolism non‐alcoholic fatty liver disease obesity oregano spice |
| url | https://doi.org/10.1002/fsn3.3939 |
| work_keys_str_mv | AT hyunjonglee ethylacetatefractionoforeganoseedprotectsnonalcoholicfattyliverinhighfatdietinducedobesemicethroughmodulationofsrebp1c AT jiyunbae ethylacetatefractionoforeganoseedprotectsnonalcoholicfattyliverinhighfatdietinducedobesemicethroughmodulationofsrebp1c AT kyewonpark ethylacetatefractionoforeganoseedprotectsnonalcoholicfattyliverinhighfatdietinducedobesemicethroughmodulationofsrebp1c AT mijakim ethylacetatefractionoforeganoseedprotectsnonalcoholicfattyliverinhighfatdietinducedobesemicethroughmodulationofsrebp1c |