Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores

Synthetic route towards potential bivalent ligands possessing opioid and D2/D3 pharmacophores

A scalable, cost-efficient and simple synthetic pathway towards potential bivalent opioid/dopamine receptor ligands was developed and optimized. Three novel compounds that contain both opioid and dopamine pharmacophores linked by the four methylene group chain were synthesized in 33, 35 and 39 % ove...

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Bibliographic Details
Main Authors:	Jevtić Ivana I., Penjišević Jelena Z., Ivanović Milovan D., Kostić-Rajačić Slađana V.
Format:	Article
Language:	English
Published:	Serbian Chemical Society 2019-01-01
Series:	Journal of the Serbian Chemical Society
Subjects:	piperidine piperazine heterocycles N-alkylation analgesics dopaminergic
Online Access:	http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391800105J.pdf

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