Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis
Abstract Background Mitochondrial dysfunction leading to disturbances in energy metabolism has emerged as one of the risk factors in the pathogenesis of depression. Numerous studies have identified alterations in the content of mitochondrial DNA (mtDNA) in peripheral blood and cerebrospinal fluid of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-05358-8 |
| _version_ | 1797451805950476288 |
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| author | Wenhui Li Lingqun Zhu Yi Chen Yudi Zhuo Shurun Wan Rongjuan Guo |
| author_facet | Wenhui Li Lingqun Zhu Yi Chen Yudi Zhuo Shurun Wan Rongjuan Guo |
| author_sort | Wenhui Li |
| collection | DOAJ |
| description | Abstract Background Mitochondrial dysfunction leading to disturbances in energy metabolism has emerged as one of the risk factors in the pathogenesis of depression. Numerous studies have identified alterations in the content of mitochondrial DNA (mtDNA) in peripheral blood and cerebrospinal fluid of individuals with depression. Researchers have sought to establish a clear association between mtDNA and depression. Consequently, we conducted a comprehensive meta-analysis to assess the existing evidence regarding the impact of mtDNA on depression. Methods This study conducted a thorough search of the following databases up to March 13, 2023: PubMed, Embase, the Cochrane Library, the Web of Science, Wanfang Database, SINOMED, the China Science and Technology Journal Database, and China National Knowledge Infrastructure. The meta-analysis was carried out using RevMan (version 5.4) and Stata (version 16.0) software. In addition, publication bias was assessed with funnel plots, Begg’s test and Egger’s test. Results Our analysis included data from 10 articles, including 12 studies for further examination. A total of 1400 participants were included in this study, comprising 709 (including 300 males and 409 females) patients with depression and 691 (including 303 males and 388 females) healthy controls. The average age of depressed patients was (42.98 ± 2.55) years, and the average age of healthy people was (41.71 ± 2.6) years. The scales used to assess outcomes are Hamilton-rating scale for Depression(4 articles), Montgomery-Asberg Depression Rating Scale(3 articles), and Mini-Internatioal Neuropsychiatric Interview (1 articles). The meta-analysis revealed significantly higher levels of mtDNA in circulating blood samples and skin fibroblasts of individuals with depression in comparison to healthy controls [standardized mean difference(SMD) = 0.42, 95% confidence intervals(CI): 0.16, 0.67]. Conclusions Our study concludes that there is a significant (p < 0.05) increase in mtDNA levels in serum, plasma, and cerebrospinal fluid in individuals with depression. These findings suggest that mtDNA could serve as a potential biomarker for diagnosing depression. Registration number PROSPERO CRD42023414285. |
| first_indexed | 2024-03-09T14:59:43Z |
| format | Article |
| id | doaj.art-1bc52b6c0b2748398bd4ee3c8a9720d2 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-09T14:59:43Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-1bc52b6c0b2748398bd4ee3c8a9720d22023-11-26T13:57:29ZengBMCBMC Psychiatry1471-244X2023-11-0123111110.1186/s12888-023-05358-8Association between mitochondrial DNA levels and depression: a systematic review and meta-analysisWenhui Li0Lingqun Zhu1Yi Chen2Yudi Zhuo3Shurun Wan4Rongjuan Guo5Dongzhimen Hospital, Beijing University of Chinese MedicineKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Key Laboratory of Dongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongfang Hospital, Beijing University of Chinese MedicineAbstract Background Mitochondrial dysfunction leading to disturbances in energy metabolism has emerged as one of the risk factors in the pathogenesis of depression. Numerous studies have identified alterations in the content of mitochondrial DNA (mtDNA) in peripheral blood and cerebrospinal fluid of individuals with depression. Researchers have sought to establish a clear association between mtDNA and depression. Consequently, we conducted a comprehensive meta-analysis to assess the existing evidence regarding the impact of mtDNA on depression. Methods This study conducted a thorough search of the following databases up to March 13, 2023: PubMed, Embase, the Cochrane Library, the Web of Science, Wanfang Database, SINOMED, the China Science and Technology Journal Database, and China National Knowledge Infrastructure. The meta-analysis was carried out using RevMan (version 5.4) and Stata (version 16.0) software. In addition, publication bias was assessed with funnel plots, Begg’s test and Egger’s test. Results Our analysis included data from 10 articles, including 12 studies for further examination. A total of 1400 participants were included in this study, comprising 709 (including 300 males and 409 females) patients with depression and 691 (including 303 males and 388 females) healthy controls. The average age of depressed patients was (42.98 ± 2.55) years, and the average age of healthy people was (41.71 ± 2.6) years. The scales used to assess outcomes are Hamilton-rating scale for Depression(4 articles), Montgomery-Asberg Depression Rating Scale(3 articles), and Mini-Internatioal Neuropsychiatric Interview (1 articles). The meta-analysis revealed significantly higher levels of mtDNA in circulating blood samples and skin fibroblasts of individuals with depression in comparison to healthy controls [standardized mean difference(SMD) = 0.42, 95% confidence intervals(CI): 0.16, 0.67]. Conclusions Our study concludes that there is a significant (p < 0.05) increase in mtDNA levels in serum, plasma, and cerebrospinal fluid in individuals with depression. These findings suggest that mtDNA could serve as a potential biomarker for diagnosing depression. Registration number PROSPERO CRD42023414285.https://doi.org/10.1186/s12888-023-05358-8DepressionmtDNAMitochondriaMeta-analysis |
| spellingShingle | Wenhui Li Lingqun Zhu Yi Chen Yudi Zhuo Shurun Wan Rongjuan Guo Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis BMC Psychiatry Depression mtDNA Mitochondria Meta-analysis |
| title | Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis |
| title_full | Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis |
| title_fullStr | Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis |
| title_full_unstemmed | Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis |
| title_short | Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis |
| title_sort | association between mitochondrial dna levels and depression a systematic review and meta analysis |
| topic | Depression mtDNA Mitochondria Meta-analysis |
| url | https://doi.org/10.1186/s12888-023-05358-8 |
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