Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing
Inflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/18/4073 |
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| author | Waqas Alam Haroon Khan Muhammad Ajmal Shah Omar Cauli Luciano Saso |
| author_facet | Waqas Alam Haroon Khan Muhammad Ajmal Shah Omar Cauli Luciano Saso |
| author_sort | Waqas Alam |
| collection | DOAJ |
| description | Inflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of inflammatory diseases. Different phytochemical constituents are present in natural products. These phytochemicals have high efficacy both in vivo and in vitro. Among them, flavonoids occur in many foods, vegetables and herbal medicines and are considered as the most active constituent, having the ability to attenuate inflammation. Kaempferol is a polyphenol that is richly found in fruits, vegetables and herbal medicines. It is also found in plant-derived beverages. Kaempferol is used in the management of various ailments but there is no available review article that can summarize all the natural sources and biological activities specifically focusing on the anti-inflammatory effect of kaempferol. Therefore, this article is aimed at providing a brief updated review of the literature regarding the anti-inflammatory effect of kaempferol and its possible molecular mechanisms of action. Furthermore, the review provides the available updated literature regarding the natural sources, chemistry, biosynthesis, oral absorption, metabolism, bioavailability and therapeutic effect of kaempferol. |
| first_indexed | 2024-03-10T16:31:28Z |
| format | Article |
| id | doaj.art-1bc554639c4e4da199d5dde44697477d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:31:28Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1bc554639c4e4da199d5dde44697477d2023-11-20T12:47:01ZengMDPI AGMolecules1420-30492020-09-012518407310.3390/molecules25184073Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic StandingWaqas Alam0Haroon Khan1Muhammad Ajmal Shah2Omar Cauli3Luciano Saso4Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, PakistanDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Nursing, University of Valencia, 46010 Valencia, SpainDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University, P.le Aldo Moro 5, 00185 Rome, ItalyInflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of inflammatory diseases. Different phytochemical constituents are present in natural products. These phytochemicals have high efficacy both in vivo and in vitro. Among them, flavonoids occur in many foods, vegetables and herbal medicines and are considered as the most active constituent, having the ability to attenuate inflammation. Kaempferol is a polyphenol that is richly found in fruits, vegetables and herbal medicines. It is also found in plant-derived beverages. Kaempferol is used in the management of various ailments but there is no available review article that can summarize all the natural sources and biological activities specifically focusing on the anti-inflammatory effect of kaempferol. Therefore, this article is aimed at providing a brief updated review of the literature regarding the anti-inflammatory effect of kaempferol and its possible molecular mechanisms of action. Furthermore, the review provides the available updated literature regarding the natural sources, chemistry, biosynthesis, oral absorption, metabolism, bioavailability and therapeutic effect of kaempferol.https://www.mdpi.com/1420-3049/25/18/4073flavonoidskaempferolinflammationtherapeutic utility |
| spellingShingle | Waqas Alam Haroon Khan Muhammad Ajmal Shah Omar Cauli Luciano Saso Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing Molecules flavonoids kaempferol inflammation therapeutic utility |
| title | Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing |
| title_full | Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing |
| title_fullStr | Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing |
| title_full_unstemmed | Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing |
| title_short | Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing |
| title_sort | kaempferol as a dietary anti inflammatory agent current therapeutic standing |
| topic | flavonoids kaempferol inflammation therapeutic utility |
| url | https://www.mdpi.com/1420-3049/25/18/4073 |
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