Refractory thrombocytopenia in a severe COVID-19 patient
Severe acute respiratory syndromerelated coronavirus 2 (SARS-CoV-2) infection has spread worldwide. The most of patients presents fever, dyspnea and cough as a typical viral infection, others show peculiar clinical and laboratory signs, such as anosmia, ageusia and thrombocytopenia. We here describe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2021-06-01
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| Series: | Geriatric Care |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/gc/article/view/9614 |
| _version_ | 1817981592574885888 |
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| author | Mirko Di Capua Alessio Conca Simone Testa Maria Mascolo Stefano Paglia |
| author_facet | Mirko Di Capua Alessio Conca Simone Testa Maria Mascolo Stefano Paglia |
| author_sort | Mirko Di Capua |
| collection | DOAJ |
| description | Severe acute respiratory syndromerelated coronavirus 2 (SARS-CoV-2) infection has spread worldwide. The most of patients presents fever, dyspnea and cough as a typical viral infection, others show peculiar clinical and laboratory signs, such as anosmia, ageusia and thrombocytopenia. We here describe a severe coronavirus disease 2019 patient (76-year old, male) that developed an immune thrombocytopenia and acquired pseudo-thrombocytopenia that were refractory to immunomodulators even after resolution of respiratory failure. The patient developed thrombocytopenia (platelets 88,000/mm3) that got worse the following day (14,000/mm3). We started 1 mg/kg of methylprednisolone i.v. daily. Platelet count increased up to 209,000/mm3, in sodium citrate, but remained about 14,000/mm3 in EDTA 10 days after the beginning of methylprednisolone. The patient showed great improvement in respiratory parameters and radiological finding. About one week after he developed a thrombocytopenia up to 70,000/mm3. We did not modify the steroids dosage. Platelet count slowly began to increase and in about 10 days returned to normal values. |
| first_indexed | 2024-04-13T23:09:18Z |
| format | Article |
| id | doaj.art-1bc56a5140454d6285a8e9826d5f3079 |
| institution | Directory Open Access Journal |
| issn | 2465-1109 2465-1397 |
| language | English |
| last_indexed | 2024-04-13T23:09:18Z |
| publishDate | 2021-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Geriatric Care |
| spelling | doaj.art-1bc56a5140454d6285a8e9826d5f30792022-12-22T02:25:37ZengPAGEPress PublicationsGeriatric Care2465-11092465-13972021-06-017210.4081/gc.2021.9614Refractory thrombocytopenia in a severe COVID-19 patientMirko Di Capua0Alessio Conca1Simone Testa2Maria Mascolo3Stefano Paglia4Emergency Department, ASST LodiEmergency Department, ASST LodiEmergency Department, ASST LodiEmergency Department, ASST LodiEmergency Department, ASST LodiSevere acute respiratory syndromerelated coronavirus 2 (SARS-CoV-2) infection has spread worldwide. The most of patients presents fever, dyspnea and cough as a typical viral infection, others show peculiar clinical and laboratory signs, such as anosmia, ageusia and thrombocytopenia. We here describe a severe coronavirus disease 2019 patient (76-year old, male) that developed an immune thrombocytopenia and acquired pseudo-thrombocytopenia that were refractory to immunomodulators even after resolution of respiratory failure. The patient developed thrombocytopenia (platelets 88,000/mm3) that got worse the following day (14,000/mm3). We started 1 mg/kg of methylprednisolone i.v. daily. Platelet count increased up to 209,000/mm3, in sodium citrate, but remained about 14,000/mm3 in EDTA 10 days after the beginning of methylprednisolone. The patient showed great improvement in respiratory parameters and radiological finding. About one week after he developed a thrombocytopenia up to 70,000/mm3. We did not modify the steroids dosage. Platelet count slowly began to increase and in about 10 days returned to normal values.https://www.pagepressjournals.org/index.php/gc/article/view/9614COVID-19immune thrombocytopeniarespiratory failure. |
| spellingShingle | Mirko Di Capua Alessio Conca Simone Testa Maria Mascolo Stefano Paglia Refractory thrombocytopenia in a severe COVID-19 patient Geriatric Care COVID-19 immune thrombocytopenia respiratory failure. |
| title | Refractory thrombocytopenia in a severe COVID-19 patient |
| title_full | Refractory thrombocytopenia in a severe COVID-19 patient |
| title_fullStr | Refractory thrombocytopenia in a severe COVID-19 patient |
| title_full_unstemmed | Refractory thrombocytopenia in a severe COVID-19 patient |
| title_short | Refractory thrombocytopenia in a severe COVID-19 patient |
| title_sort | refractory thrombocytopenia in a severe covid 19 patient |
| topic | COVID-19 immune thrombocytopenia respiratory failure. |
| url | https://www.pagepressjournals.org/index.php/gc/article/view/9614 |
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