Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway
Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having a multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, and most importantly, the association betw...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223016037 |
| _version_ | 1797630578379456512 |
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| author | Marjan Talebi Mohammad Mehdi Sadoughi Seyed Abdulmajid Ayatollahi Elaheh Ainy Roghayeh Kiani Alireza Zali MirMohammad Miri |
| author_facet | Marjan Talebi Mohammad Mehdi Sadoughi Seyed Abdulmajid Ayatollahi Elaheh Ainy Roghayeh Kiani Alireza Zali MirMohammad Miri |
| author_sort | Marjan Talebi |
| collection | DOAJ |
| description | Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having a multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, and most importantly, the association between the therapeutic potential of CBD and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The relationship between Nrf2 and CBD is closely linked to certain proteins that are associated with cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Specifically, Nrf2 is connected to the initiation and progression of diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, cancers, obesity, myocardial injury and angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's disease, Parkinson's disease, neuroinflammation, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. The association between CBD and Nrf2 is a zone of great interest in the medical field, as it has the potential to significantly impact the treatment and prevention of wide-ranging health conditions. Additional investigation is necessary to entirely apprehend the mechanisms underlying this crucial interplay and to develop effective therapeutic interventions. |
| first_indexed | 2024-03-11T11:10:09Z |
| format | Article |
| id | doaj.art-1bc7c55aa5984f0d83be5d9c17981304 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:10:09Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-1bc7c55aa5984f0d83be5d9c179813042023-11-12T04:39:23ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115805Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathwayMarjan Talebi0Mohammad Mehdi Sadoughi1Seyed Abdulmajid Ayatollahi2Elaheh Ainy3Roghayeh Kiani4Alireza Zali5MirMohammad Miri6Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSafety Promotion and Injury Prevention Research Center, Department of Vice Chancellor Research Affairs, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranShohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Neurosurgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding aurthor at: Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Anesthesiology and Critical Care, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Correspondence to: Department of Anesthesiology and Critical Care, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, 1617763141, Tehran, Iran.Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having a multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, and most importantly, the association between the therapeutic potential of CBD and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The relationship between Nrf2 and CBD is closely linked to certain proteins that are associated with cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Specifically, Nrf2 is connected to the initiation and progression of diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, cancers, obesity, myocardial injury and angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's disease, Parkinson's disease, neuroinflammation, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. The association between CBD and Nrf2 is a zone of great interest in the medical field, as it has the potential to significantly impact the treatment and prevention of wide-ranging health conditions. Additional investigation is necessary to entirely apprehend the mechanisms underlying this crucial interplay and to develop effective therapeutic interventions.http://www.sciencedirect.com/science/article/pii/S0753332223016037CannabidiolCannabis sativaNeurological diseasesNrf2Nuclear factor erythroid 2-related factor 2Signaling pathway |
| spellingShingle | Marjan Talebi Mohammad Mehdi Sadoughi Seyed Abdulmajid Ayatollahi Elaheh Ainy Roghayeh Kiani Alireza Zali MirMohammad Miri Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway Biomedicine & Pharmacotherapy Cannabidiol Cannabis sativa Neurological diseases Nrf2 Nuclear factor erythroid 2-related factor 2 Signaling pathway |
| title | Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway |
| title_full | Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway |
| title_fullStr | Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway |
| title_full_unstemmed | Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway |
| title_short | Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway |
| title_sort | therapeutic potentials of cannabidiol focus on the nrf2 signaling pathway |
| topic | Cannabidiol Cannabis sativa Neurological diseases Nrf2 Nuclear factor erythroid 2-related factor 2 Signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223016037 |
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