Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice

Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice

Strategies to combat COVID-19 require multiple ways to protect vulnerable people from infection. SARS-CoV-2 is an airborne pathogen and the nasal cavity is a primary target of infection. The K18-hACE2 mouse model was used to investigate the anti-SARS-CoV-2 efficacy of astodrimer sodium formulated in...

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Bibliographic Details
Main Authors: Jeremy R. A. Paull, Carolyn A. Luscombe, Alex Castellarnau, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
astodrimer
SPL7013
dendrimer
antiviral
SARS-CoV-2
COVID-19
Online Access:https://www.mdpi.com/1999-4915/13/8/1656

Internet

https://www.mdpi.com/1999-4915/13/8/1656

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