Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus
Abstract Background To compare the outcomes of two different protocols of accelerated corneal crosslinking (CXL) on visual, corneal high order aberrations (HOA) and topographic parameters in patients with progressive keratoconus. Methods In this prospective comparative study, sixty-six eyes of 66 pa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-06-01
|
| Series: | Eye and Vision |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40662-019-0141-6 |
| _version_ | 1818974475394220032 |
|---|---|
| author | Ahmet Kirgiz Mustafa Eliacik Yusuf Yildirim |
| author_facet | Ahmet Kirgiz Mustafa Eliacik Yusuf Yildirim |
| author_sort | Ahmet Kirgiz |
| collection | DOAJ |
| description | Abstract Background To compare the outcomes of two different protocols of accelerated corneal crosslinking (CXL) on visual, corneal high order aberrations (HOA) and topographic parameters in patients with progressive keratoconus. Methods In this prospective comparative study, sixty-six eyes of 66 patients with progressive keratoconus were divided into two groups; 37 eyes in Group 1 received 18 mW/cm2 for five minutes, and 29 eyes in Group 2 were treated with 9 mW/cm2 for 10 min. The uncorrected distant visual acuity (UCVA), best-corrected distant visual acuity (BCVA), corneal HOAs and topography parameters were measured preoperatively and postoperatively at the end of 12 months. The data for the two groups were compared statistically. Results The mean UCVA and BCVA were significantly improved at the postoperative 12 months compared with the preoperative values in both groups (P < 0.05 for all). A significant improvement in corneal HOAs was observed in both groups (P < 0.05 for all). The change in corneal coma value was significantly higher in Group 2 (P < 0.05). The change in keratometric values K1, K2, AvgK and maximum keratometry (AKf) were significantly higher in Group 2 (P < 0.05 for all). The regression model showed that the most important factor predicting the change in AKf was the type of CXL (β = − 0.482, P = 0.005). Conclusions Accelerated CXL using 10 min of UVA irradiance at 9 mW/cm2 showed better topographic improvements and coma values than five minutes of UVA irradiance at 18 mW/cm2 independent of keratoconus severity. |
| first_indexed | 2024-12-20T15:40:39Z |
| format | Article |
| id | doaj.art-1bc8513b9d544e8b8c65b776db53b3bf |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-12-20T15:40:39Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-1bc8513b9d544e8b8c65b776db53b3bf2022-12-21T19:35:11ZengBMCEye and Vision2326-02542019-06-01611910.1186/s40662-019-0141-6Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconusAhmet Kirgiz0Mustafa Eliacik1Yusuf Yildirim2Department of Ophthalmology, University of Health Sciences, Bagcilar Training and Research HospitalDepartment of Ophthalmology, Istanbul Medipol UniversityUniversity of Health Sciences, Beyoglu Eye Training and Research HospitalAbstract Background To compare the outcomes of two different protocols of accelerated corneal crosslinking (CXL) on visual, corneal high order aberrations (HOA) and topographic parameters in patients with progressive keratoconus. Methods In this prospective comparative study, sixty-six eyes of 66 patients with progressive keratoconus were divided into two groups; 37 eyes in Group 1 received 18 mW/cm2 for five minutes, and 29 eyes in Group 2 were treated with 9 mW/cm2 for 10 min. The uncorrected distant visual acuity (UCVA), best-corrected distant visual acuity (BCVA), corneal HOAs and topography parameters were measured preoperatively and postoperatively at the end of 12 months. The data for the two groups were compared statistically. Results The mean UCVA and BCVA were significantly improved at the postoperative 12 months compared with the preoperative values in both groups (P < 0.05 for all). A significant improvement in corneal HOAs was observed in both groups (P < 0.05 for all). The change in corneal coma value was significantly higher in Group 2 (P < 0.05). The change in keratometric values K1, K2, AvgK and maximum keratometry (AKf) were significantly higher in Group 2 (P < 0.05 for all). The regression model showed that the most important factor predicting the change in AKf was the type of CXL (β = − 0.482, P = 0.005). Conclusions Accelerated CXL using 10 min of UVA irradiance at 9 mW/cm2 showed better topographic improvements and coma values than five minutes of UVA irradiance at 18 mW/cm2 independent of keratoconus severity.http://link.springer.com/article/10.1186/s40662-019-0141-6Accelerated crosslinkingCorneal collagen CXLHigh order aberrationsKeratoconusTopography |
| spellingShingle | Ahmet Kirgiz Mustafa Eliacik Yusuf Yildirim Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus Eye and Vision Accelerated crosslinking Corneal collagen CXL High order aberrations Keratoconus Topography |
| title | Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus |
| title_full | Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus |
| title_fullStr | Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus |
| title_full_unstemmed | Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus |
| title_short | Different accelerated corneal collagen cross-linking treatment modalities in progressive keratoconus |
| title_sort | different accelerated corneal collagen cross linking treatment modalities in progressive keratoconus |
| topic | Accelerated crosslinking Corneal collagen CXL High order aberrations Keratoconus Topography |
| url | http://link.springer.com/article/10.1186/s40662-019-0141-6 |
| work_keys_str_mv | AT ahmetkirgiz differentacceleratedcornealcollagencrosslinkingtreatmentmodalitiesinprogressivekeratoconus AT mustafaeliacik differentacceleratedcornealcollagencrosslinkingtreatmentmodalitiesinprogressivekeratoconus AT yusufyildirim differentacceleratedcornealcollagencrosslinkingtreatmentmodalitiesinprogressivekeratoconus |