Phosphorylation-Mediated Activation of β-Catenin-TCF4-CEGRs/ALCDs Pathway Is an Essential Event in Development of Aggressive Hepatoblastoma

Phosphorylation-Mediated Activation of β-Catenin-TCF4-CEGRs/ALCDs Pathway Is an Essential Event in Development of Aggressive Hepatoblastoma

Background and Aims: Hepatoblastoma (HBL), a deadly malignancy in children, is the most common type of pediatric liver cancer. We recently demonstrated that β-catenin, phosphorylated at S675 (ph-S675-β-catenin), causes pathological alterations in fibrolamellar hepatocellular carcinoma (FLC), by acti...

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Bibliographic Details
Main Authors: Ruhi Gulati, Margaret A. Hanlon, Maggie Lutz, Tyler Quitmeyer, James Geller, Gregory Tiao, Lubov Timchenko, Nikolai Timchenko
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
hepatoblastoma
liver cancer
epigenetics
β-catenin
Online Access:https://www.mdpi.com/2072-6694/14/24/6062

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