Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus transmission, geographic spread, and disease severity. We find that multiple alphaviruses, including chikungunya (CHIKV), Ross River (RRV), and o’nyong ‘nyong (ONNV) viruses, are cleared from the circulation of m...

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Bibliographic Details
Main Authors: Kathryn S Carpentier, Bennett J Davenport, Kelsey C Haist, Mary K McCarthy, Nicholas A May, Alexis Robison, Claudia Ruckert, Gregory D Ebel, Thomas E Morrison
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
arbovirus
scavenger receptor
innate immunity
alphavirus
Online Access:https://elifesciences.org/articles/49163

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