Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis
Background: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or sh...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-10-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00488/full |
| _version_ | 1818244746390274048 |
|---|---|
| author | Martina Rojnic Kuzman Martina Rojnic Kuzman Dina Bosnjak Kuharic Ivana Kekin Porin Makaric Zoran Madzarac Ana Koricancic Makar Suzan Kudlek Mikulic Zarko Bajic Petra Bistrovic Dora Bonacin Zeljka Vogrinc |
| author_facet | Martina Rojnic Kuzman Martina Rojnic Kuzman Dina Bosnjak Kuharic Ivana Kekin Porin Makaric Zoran Madzarac Ana Koricancic Makar Suzan Kudlek Mikulic Zarko Bajic Petra Bistrovic Dora Bonacin Zeljka Vogrinc |
| author_sort | Martina Rojnic Kuzman |
| collection | DOAJ |
| description | Background: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or short-term effects. This study aims to analyse the effects of a long-term multimodal treatment program for first episode psychosis on antipsychotic-induced metabolic changes.Methods: We enrolled 71 patients with first episode psychosis treated at the Zagreb University Hospital Centre from 2016 until 2018. Participants were assigned to one of the two groups: day hospital program vs. treatment as usual (TAU). Outcomes were: body weight, blood glucose, lipids and cholesterol, psychopathology and global level of functioning during the 18-months follow-up.Results: Although the TAU group gained more weight and had higher increase of blood glucose, while the day hospital group had a higher increase in total cholesterol at 18th month follow-up, after the adjustment for age, gender and baseline measures, the type of treatment was not significantly associated with any of the primary outcome measures. Patients' psychopathology measures significantly decreased and their functional level significantly increased at month 18th in both groups.Conclusion: While both types of treatment were effective in reducing psychopathology and restoring the patients' level of functioning, both were relatively ineffective in counteracting antipsychotic-induced metabolic abnormalities and antipsychotic-induced weight gain. |
| first_indexed | 2024-12-12T14:21:55Z |
| format | Article |
| id | doaj.art-1bcc2b439b5d4513941adf9cf6ee52fd |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T14:21:55Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-1bcc2b439b5d4513941adf9cf6ee52fd2022-12-22T00:21:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-10-01910.3389/fpsyt.2018.00488417012Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode PsychosisMartina Rojnic Kuzman0Martina Rojnic Kuzman1Dina Bosnjak Kuharic2Ivana Kekin3Porin Makaric4Zoran Madzarac5Ana Koricancic Makar6Suzan Kudlek Mikulic7Zarko Bajic8Petra Bistrovic9Dora Bonacin10Zeljka Vogrinc11Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, CroatiaZagreb School of Medicine, University of Zagreb, Zagreb, CroatiaPsychiatric Hospital Vrapce, Zagreb, CroatiaDepartment of Psychiatry, University Hospital Centre Zagreb, Zagreb, CroatiaPsychiatric Hospital Vrapce, Zagreb, CroatiaDepartment of Psychiatry, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Psychiatry, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Psychiatry, University Hospital Centre Zagreb, Zagreb, CroatiaBiometrika Healthcare Research, Zagreb, CroatiaZagreb School of Medicine, University of Zagreb, Zagreb, CroatiaZagreb School of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, CroatiaBackground: Antipsychotic-induced weight gain and metabolic abnormalities are one of the major challenges in the treatment of psychosis, contributing to the morbidity, mortality and treatment non-adherence. Different approaches were used to counteract these side effects but showed only limited or short-term effects. This study aims to analyse the effects of a long-term multimodal treatment program for first episode psychosis on antipsychotic-induced metabolic changes.Methods: We enrolled 71 patients with first episode psychosis treated at the Zagreb University Hospital Centre from 2016 until 2018. Participants were assigned to one of the two groups: day hospital program vs. treatment as usual (TAU). Outcomes were: body weight, blood glucose, lipids and cholesterol, psychopathology and global level of functioning during the 18-months follow-up.Results: Although the TAU group gained more weight and had higher increase of blood glucose, while the day hospital group had a higher increase in total cholesterol at 18th month follow-up, after the adjustment for age, gender and baseline measures, the type of treatment was not significantly associated with any of the primary outcome measures. Patients' psychopathology measures significantly decreased and their functional level significantly increased at month 18th in both groups.Conclusion: While both types of treatment were effective in reducing psychopathology and restoring the patients' level of functioning, both were relatively ineffective in counteracting antipsychotic-induced metabolic abnormalities and antipsychotic-induced weight gain.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00488/fullantipsychoticsschizophreniafirst episode psychosismetabolic abnormalitiesweight gainpsychosocial intervention |
| spellingShingle | Martina Rojnic Kuzman Martina Rojnic Kuzman Dina Bosnjak Kuharic Ivana Kekin Porin Makaric Zoran Madzarac Ana Koricancic Makar Suzan Kudlek Mikulic Zarko Bajic Petra Bistrovic Dora Bonacin Zeljka Vogrinc Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis Frontiers in Psychiatry antipsychotics schizophrenia first episode psychosis metabolic abnormalities weight gain psychosocial intervention |
| title | Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis |
| title_full | Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis |
| title_fullStr | Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis |
| title_full_unstemmed | Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis |
| title_short | Effects of Long-Term Multimodal Psychosocial Treatment on Antipsychotic-Induced Metabolic Changes in Patients With First Episode Psychosis |
| title_sort | effects of long term multimodal psychosocial treatment on antipsychotic induced metabolic changes in patients with first episode psychosis |
| topic | antipsychotics schizophrenia first episode psychosis metabolic abnormalities weight gain psychosocial intervention |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00488/full |
| work_keys_str_mv | AT martinarojnickuzman effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT martinarojnickuzman effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT dinabosnjakkuharic effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT ivanakekin effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT porinmakaric effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT zoranmadzarac effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT anakoricancicmakar effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT suzankudlekmikulic effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT zarkobajic effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT petrabistrovic effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT dorabonacin effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis AT zeljkavogrinc effectsoflongtermmultimodalpsychosocialtreatmentonantipsychoticinducedmetabolicchangesinpatientswithfirstepisodepsychosis |