Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program
Introduction: Albumin is considered an important extracellular antioxidant molecule. hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis. The present study evaluated the relation between hypoalbuminemia and oxidative stress by comparing superoxide dismutase...
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
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| Series: | Nutrición Hospitalaria |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001100034&lng=en&tlng=en |
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| author | Lais Lima de Castro Maria do Carmo de Carvalho e Martins Anderson Mendes Garcez James Frederico Rocha Pacheco Francisco Valmor Macedo Cunha José Machado Moita Neto Manoela Carine Lima de Freitas Luan Arnon de Melo Cunha |
| author_facet | Lais Lima de Castro Maria do Carmo de Carvalho e Martins Anderson Mendes Garcez James Frederico Rocha Pacheco Francisco Valmor Macedo Cunha José Machado Moita Neto Manoela Carine Lima de Freitas Luan Arnon de Melo Cunha |
| author_sort | Lais Lima de Castro |
| collection | DOAJ |
| description | Introduction: Albumin is considered an important extracellular antioxidant molecule. hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis. The present study evaluated the relation between hypoalbuminemia and oxidative stress by comparing superoxide dismutase activity, lipid peroxidation and antioxidant micronutrient consumption in chronic renal failure patients. Methods: A case-control study was carried out with 64 patients of both sexes aged 18 to 59 years. The patients with hypoalbuminemia (ALB <3.5 g/dL) were defined as case (n = 26) and control (n = 38) those with ALB ≥ 3.5 g/dL. Determinations of activity superoxide dismutase (SOD) and nitric oxide production by the contraction of nitrite in erythrocytes, concentration of malondialdehyde (MDA) in plasma, lipid profile and micronutrient antioxidants intake were performed. For comparisons between groups, the Student t test was used. Possible associations between variables were tested using the chi-square test and Pearson correlation test. Results: Consumption of copper was significantly lower (p < 0.05) in the group with hypoalbuminemia. There was a positive correlation between the concentrations of albumin and intake copper (r = 0.280). Negative correlation was found between albumin and MDA concentrations. Conclusion: Hypoalbuminemia is associated with increased lipid peroxidation, and can contribute to oxidative stress in chronic renal failure patients. Additionally, patients with chronic renal disease undergoing hemodialysis evaluated in this study had reduced consumption of cooper. |
| first_indexed | 2024-12-11T13:44:18Z |
| format | Article |
| id | doaj.art-1bcd0023bd8d4152bc89de1f7aae72c2 |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-11T13:44:18Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-1bcd0023bd8d4152bc89de1f7aae72c22022-12-22T01:04:35ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161130495295910.3305/nh.2014.30.4.7667S0212-16112014001100034Hypoalbuminemia and oxidative stress in patients on renal hemodialysis programLais Lima de CastroMaria do Carmo de Carvalho e Martins0Anderson Mendes GarcezJames Frederico Rocha PachecoFrancisco Valmor Macedo CunhaJosé Machado Moita Neto1Manoela Carine Lima de FreitasLuan Arnon de Melo CunhaFederal University of PiauiFederal University of PiauiIntroduction: Albumin is considered an important extracellular antioxidant molecule. hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis. The present study evaluated the relation between hypoalbuminemia and oxidative stress by comparing superoxide dismutase activity, lipid peroxidation and antioxidant micronutrient consumption in chronic renal failure patients. Methods: A case-control study was carried out with 64 patients of both sexes aged 18 to 59 years. The patients with hypoalbuminemia (ALB <3.5 g/dL) were defined as case (n = 26) and control (n = 38) those with ALB ≥ 3.5 g/dL. Determinations of activity superoxide dismutase (SOD) and nitric oxide production by the contraction of nitrite in erythrocytes, concentration of malondialdehyde (MDA) in plasma, lipid profile and micronutrient antioxidants intake were performed. For comparisons between groups, the Student t test was used. Possible associations between variables were tested using the chi-square test and Pearson correlation test. Results: Consumption of copper was significantly lower (p < 0.05) in the group with hypoalbuminemia. There was a positive correlation between the concentrations of albumin and intake copper (r = 0.280). Negative correlation was found between albumin and MDA concentrations. Conclusion: Hypoalbuminemia is associated with increased lipid peroxidation, and can contribute to oxidative stress in chronic renal failure patients. Additionally, patients with chronic renal disease undergoing hemodialysis evaluated in this study had reduced consumption of cooper.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001100034&lng=en&tlng=enChronic kidney diseaseHypoalbuminemiaMicronutrientsLipid peroxidationSuperoxide dismutase |
| spellingShingle | Lais Lima de Castro Maria do Carmo de Carvalho e Martins Anderson Mendes Garcez James Frederico Rocha Pacheco Francisco Valmor Macedo Cunha José Machado Moita Neto Manoela Carine Lima de Freitas Luan Arnon de Melo Cunha Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program Nutrición Hospitalaria Chronic kidney disease Hypoalbuminemia Micronutrients Lipid peroxidation Superoxide dismutase |
| title | Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| title_full | Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| title_fullStr | Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| title_full_unstemmed | Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| title_short | Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| title_sort | hypoalbuminemia and oxidative stress in patients on renal hemodialysis program |
| topic | Chronic kidney disease Hypoalbuminemia Micronutrients Lipid peroxidation Superoxide dismutase |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014001100034&lng=en&tlng=en |
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