Highly mismatch-tolerant homology testing by RecA could explain how homology length affects recombination.
In E. coli, double strand breaks (DSBs) are resected and loaded with RecA protein. The genome is then rapidly searched for a sequence that is homologous to the DNA flanking the DSB. Mismatches in homologous partners are rare, suggesting that RecA should rapidly reject mismatched recombination produc...
Main Authors: | Mara Prentiss, Dianzhuo Wang, Jonathan Fu, Chantal Prévost, Veronica Godoy-Carter, Nancy Kleckner, Claudia Danilowicz |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-01-01
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Series: | PLoS ONE |
Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288611&type=printable |
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