Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination. We expose natural killer (NK) cells as robust negative regulators of somatic hypermutation in antigen-reactive B cells. NK...

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Bibliographic Details
Main Authors: Carolyn E. Rydyznski, Stacey A. Cranert, Julian Q. Zhou, Heping Xu, Steven H. Kleinstein, Harinder Singh, Stephen N. Waggoner
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718313792

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