Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a We...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15847-z |
| _version_ | 1828954833378344960 |
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| author | Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker |
| author_facet | Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker |
| author_sort | Lindsey S. Treviño |
| collection | DOAJ |
| description | Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet. |
| first_indexed | 2024-12-14T07:37:41Z |
| format | Article |
| id | doaj.art-1bd07351812944de819b5ad960475b3b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:37:41Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1bd07351812944de819b5ad960475b3b2022-12-21T23:11:08ZengNature PortfolioNature Communications2041-17232020-05-0111111410.1038/s41467-020-15847-zEpigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthoodLindsey S. Treviño0Jianrong Dong1Ahkilesh Kaushal2Tiffany A. Katz3Rahul Kumar Jangid4Matthew J. Robertson5Sandra L. Grimm6Chandra Shekar R. Ambati7Vasanta Putluri8Aaron R. Cox9Kang Ho Kim10Thaddeus D. May11Morgan R. Gallo12David D. Moore13Sean M. Hartig14Charles E. Foulds15Nagireddy Putluri16Cristian Coarfa17Cheryl Lyn Walker18Center for Precision Environmental Health, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineAdvanced Technology Cores, Baylor College of MedicineAdvanced Technology Cores, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineAdvanced Technology Cores, Baylor College of MedicineDepartment of Medicine, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Pediatrics, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineCenter for Precision Environmental Health, Baylor College of MedicineEarly life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcriptionally silent until animals are placed on a Western-style diet.https://doi.org/10.1038/s41467-020-15847-z |
| spellingShingle | Lindsey S. Treviño Jianrong Dong Ahkilesh Kaushal Tiffany A. Katz Rahul Kumar Jangid Matthew J. Robertson Sandra L. Grimm Chandra Shekar R. Ambati Vasanta Putluri Aaron R. Cox Kang Ho Kim Thaddeus D. May Morgan R. Gallo David D. Moore Sean M. Hartig Charles E. Foulds Nagireddy Putluri Cristian Coarfa Cheryl Lyn Walker Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood Nature Communications |
| title | Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| title_full | Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| title_fullStr | Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| title_full_unstemmed | Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| title_short | Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| title_sort | epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood |
| url | https://doi.org/10.1038/s41467-020-15847-z |
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