Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR) Modeling of Amino–Imino Tautomers

Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR) Modeling of Amino–Imino Tautomers

In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C) of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB). Now, we report the anti-MTB and cytotoxicity evaluations of a new series...

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Bibliographic Details
Main Authors: Marcelle L. F. Bispo, Camilo H. S. Lima, Laura N. F. Cardoso, André L. P. Candéa, Flávio A. F. M. Bezerra, Maria C. S. Lourenço, Maria G. M. O. Henriques, Ricardo B. Alencastro, Carlos R. Kaiser, Marcus V. N. Souza, Magaly G. Albuquerque
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Pharmaceuticals
Subjects:
Mycobacterium tuberculosis
4-aminoquinoline
amino–imino tautomerism
molecular modeling
hologram quantitative structure–activity relationship (HQSAR)
drug design
anti-mycobacterial activity
cytotoxicity
Online Access:http://www.mdpi.com/1424-8247/10/2/52

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