Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies
BackgroundHashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.860880/full |
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| author | Georgios Boutzios Eleni Koukoulioti Andreas V. Goules Ioannis Kalliakmanis Ilias Giovannopoulos Panayiotis Vlachoyiannopoulos Haralampos M. Moutsopoulos Haralampos M. Moutsopoulos Athanasios G. Tzioufas |
| author_facet | Georgios Boutzios Eleni Koukoulioti Andreas V. Goules Ioannis Kalliakmanis Ilias Giovannopoulos Panayiotis Vlachoyiannopoulos Haralampos M. Moutsopoulos Haralampos M. Moutsopoulos Athanasios G. Tzioufas |
| author_sort | Georgios Boutzios |
| collection | DOAJ |
| description | BackgroundHashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of this study was to investigate, in a cohort of HT patients: a) the prevalence of APCA in an attempt to define their clinical phenotype and b) any possible associations of APCA with other autoimmune diseases and malignancies.MethodsThis is a single-center, case-control study, conducted at a University Hospital. The study included patients with HT diagnosed between November 2017 and November 2020. Excluded were patients <18 years old, with sonographic features of HT but negative thyroid peroxidase (TPOAbs) or thyroglobulin autoantibodies (TgAbs), Graves’ disease, Down or Turner’s syndrome.ResultsA total of 840 patients with HT were included in the study, from whom 180 (21.4%) had positive APCA. A total of 79 patients (9.4%) had one or more organ-specific autoimmune diseases and 61 (7.3%) had a systemic autoimmune disease. Autoimmune diseases were more frequent in female than in male patients (17.9% versus 10.9%, p = 0.05). APCA-positive patients were older than APCA-negative (54.1 ± 13.5 versus 49.0 ± 14.6, p <0.001) and had more often positive TPOAbs (93.3% versus 83.9%, p=0.001). Gastric neoplasms were documented only in APCA-positive patients (p <0.001). A higher frequency of organ-specific autoimmune diseases was observed in the APCA-positive group (14.4% versus 8%, p = 0.024). In the subgroup of patients with additional autoimmune diseases (n = 140), younger age and positive APCA were independently associated with the presence of organ-specific autoimmunity (OR 0.954, 95% CI 0.927–0.982 and OR 3.100, 95% CI 1.256–7.652, respectively). Papillary thyroid cancer (PTC) occurred in 3.5% of patients (26/29 women). Positive family history for thyroid autoimmunity and negative TPOAbs were the only independent risk factors for PTC among women (OR 3.228, 95% CI 1.173–8.887 and 0.315, 95% 0.113–0.881, respectively).ConclusionThis study reveals for the first time an association of APCA with organ-specific autoimmunity in HT patients. APCA together with patient age were independently associated with the presence of organ-specific autoimmunity. Finally, this study showed an association between APCA and gastric neoplasms in these patients. |
| first_indexed | 2024-12-12T23:12:25Z |
| format | Article |
| id | doaj.art-1bd115ffc3e44640bf39f9163000fc46 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T23:12:25Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1bd115ffc3e44640bf39f9163000fc462022-12-22T00:08:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-04-011310.3389/fendo.2022.860880860880Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and MalignanciesGeorgios Boutzios0Eleni Koukoulioti1Andreas V. Goules2Ioannis Kalliakmanis3Ilias Giovannopoulos4Panayiotis Vlachoyiannopoulos5Haralampos M. Moutsopoulos6Haralampos M. Moutsopoulos7Athanasios G. Tzioufas8Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceEndoscopy Unit, Ygeia Hospital AE, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceAcademy of Athens, Athens, GreeceDepartment of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceBackgroundHashimoto thyroiditis (HT) is an autoimmune disease which may result in extensive damage of the thyroid gland. Chronic atrophic gastritis (CAG), is the most frequent HT-associated disorder, with anti-parietal cell autoantibodies (APCA) being a screening test for autoimmune CAG. The aim of this study was to investigate, in a cohort of HT patients: a) the prevalence of APCA in an attempt to define their clinical phenotype and b) any possible associations of APCA with other autoimmune diseases and malignancies.MethodsThis is a single-center, case-control study, conducted at a University Hospital. The study included patients with HT diagnosed between November 2017 and November 2020. Excluded were patients <18 years old, with sonographic features of HT but negative thyroid peroxidase (TPOAbs) or thyroglobulin autoantibodies (TgAbs), Graves’ disease, Down or Turner’s syndrome.ResultsA total of 840 patients with HT were included in the study, from whom 180 (21.4%) had positive APCA. A total of 79 patients (9.4%) had one or more organ-specific autoimmune diseases and 61 (7.3%) had a systemic autoimmune disease. Autoimmune diseases were more frequent in female than in male patients (17.9% versus 10.9%, p = 0.05). APCA-positive patients were older than APCA-negative (54.1 ± 13.5 versus 49.0 ± 14.6, p <0.001) and had more often positive TPOAbs (93.3% versus 83.9%, p=0.001). Gastric neoplasms were documented only in APCA-positive patients (p <0.001). A higher frequency of organ-specific autoimmune diseases was observed in the APCA-positive group (14.4% versus 8%, p = 0.024). In the subgroup of patients with additional autoimmune diseases (n = 140), younger age and positive APCA were independently associated with the presence of organ-specific autoimmunity (OR 0.954, 95% CI 0.927–0.982 and OR 3.100, 95% CI 1.256–7.652, respectively). Papillary thyroid cancer (PTC) occurred in 3.5% of patients (26/29 women). Positive family history for thyroid autoimmunity and negative TPOAbs were the only independent risk factors for PTC among women (OR 3.228, 95% CI 1.173–8.887 and 0.315, 95% 0.113–0.881, respectively).ConclusionThis study reveals for the first time an association of APCA with organ-specific autoimmunity in HT patients. APCA together with patient age were independently associated with the presence of organ-specific autoimmunity. Finally, this study showed an association between APCA and gastric neoplasms in these patients.https://www.frontiersin.org/articles/10.3389/fendo.2022.860880/fullHashimoto thyroiditisanti-parietal cell antibodiesorgan-specific autoimmunitysystemic autoimmunitygastric malignancies |
| spellingShingle | Georgios Boutzios Eleni Koukoulioti Andreas V. Goules Ioannis Kalliakmanis Ilias Giovannopoulos Panayiotis Vlachoyiannopoulos Haralampos M. Moutsopoulos Haralampos M. Moutsopoulos Athanasios G. Tzioufas Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies Frontiers in Endocrinology Hashimoto thyroiditis anti-parietal cell antibodies organ-specific autoimmunity systemic autoimmunity gastric malignancies |
| title | Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies |
| title_full | Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies |
| title_fullStr | Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies |
| title_full_unstemmed | Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies |
| title_short | Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies |
| title_sort | hashimoto thyroiditis anti parietal cell antibodies associations with autoimmune diseases and malignancies |
| topic | Hashimoto thyroiditis anti-parietal cell antibodies organ-specific autoimmunity systemic autoimmunity gastric malignancies |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.860880/full |
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