Cytoplasmic and Nuclear Functions of cIAP1
Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/2/322 |
| _version_ | 1827656453772541952 |
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| author | Aymeric Zadoroznyj Laurence Dubrez |
| author_facet | Aymeric Zadoroznyj Laurence Dubrez |
| author_sort | Aymeric Zadoroznyj |
| collection | DOAJ |
| description | Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs. |
| first_indexed | 2024-03-09T22:28:40Z |
| format | Article |
| id | doaj.art-1bd1c0ae5b41473680fe1fffc5d22f7c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T22:28:40Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1bd1c0ae5b41473680fe1fffc5d22f7c2023-11-23T19:00:04ZengMDPI AGBiomolecules2218-273X2022-02-0112232210.3390/biom12020322Cytoplasmic and Nuclear Functions of cIAP1Aymeric Zadoroznyj0Laurence Dubrez1Institut National de la Santé et de la Recherche Médicale (Inserm) Inserm LNC UMR1231, LabEx LipSTIC, 21000 Dijon, FranceInstitut National de la Santé et de la Recherche Médicale (Inserm) Inserm LNC UMR1231, LabEx LipSTIC, 21000 Dijon, FranceCellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs.https://www.mdpi.com/2218-273X/12/2/322IAPssignaling pathwaysinnate immunityubiquitinationTNFαNF-κB |
| spellingShingle | Aymeric Zadoroznyj Laurence Dubrez Cytoplasmic and Nuclear Functions of cIAP1 Biomolecules IAPs signaling pathways innate immunity ubiquitination TNFα NF-κB |
| title | Cytoplasmic and Nuclear Functions of cIAP1 |
| title_full | Cytoplasmic and Nuclear Functions of cIAP1 |
| title_fullStr | Cytoplasmic and Nuclear Functions of cIAP1 |
| title_full_unstemmed | Cytoplasmic and Nuclear Functions of cIAP1 |
| title_short | Cytoplasmic and Nuclear Functions of cIAP1 |
| title_sort | cytoplasmic and nuclear functions of ciap1 |
| topic | IAPs signaling pathways innate immunity ubiquitination TNFα NF-κB |
| url | https://www.mdpi.com/2218-273X/12/2/322 |
| work_keys_str_mv | AT aymericzadoroznyj cytoplasmicandnuclearfunctionsofciap1 AT laurencedubrez cytoplasmicandnuclearfunctionsofciap1 |