Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease
Background: Eosinophilia is often observed in patients with chronic obstructive pulmonary disease (COPD), but the influence of eosinophilia on the clinical outcomes of patients with COPD is unknown. This study aimed to evaluate the clinical characteristics of eosinophilic COPD (E-COPD) and define th...
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| Format: | Article |
| Language: | English |
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Society of Tokyo Women's Medical University
2023-04-01
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| Series: | Tokyo Women's Medical University Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/twmuj/advpub/0/advpub_2022017/_pdf/-char/en |
| _version_ | 1797770654297096192 |
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| author | Mami Orimo Tomohiro Akaba Fumi Kobayashi Azusa Miyoshi Osamitsu Yagi Hideki Katsura Mitsuko Kondo Estuko Tagaya |
| author_facet | Mami Orimo Tomohiro Akaba Fumi Kobayashi Azusa Miyoshi Osamitsu Yagi Hideki Katsura Mitsuko Kondo Estuko Tagaya |
| author_sort | Mami Orimo |
| collection | DOAJ |
| description | Background: Eosinophilia is often observed in patients with chronic obstructive pulmonary disease (COPD), but the influence of eosinophilia on the clinical outcomes of patients with COPD is unknown. This study aimed to evaluate the clinical characteristics of eosinophilic COPD (E-COPD) and define the effects of treatment with inhaled corticosteroids (ICS) on cardiovascular events in patients with E-COPD. Methods: We included 398 patients with COPD and classified them into two groups: E-COPD (blood eosinophil counts >300 cells/μL or >4%) and non-E-COPD. Patient characteristics and exacerbations between the two groups were compared and the effects of ICS on these variables were studied. Results: E-COPD patients (n = 196) experienced 4.49- and 6.13-time greater numbers of moderate and severe exacerbations, respectively, than non-E-COPD patients (n = 202). In the Cox proportional hazards analysis, higher eosinophil counts and lower pulmonary function values were significantly associated with moderate and severe exacerbations. Patients with E-COPD treated with ICS had fewer cardiovascular events than those treated without ICS (relative risk, 0.39; p = 0.011). Conclusion: These results suggest that eosinophilia may be associated with increased exacerbations of COPD and that treatment with ICS may be considered to reduce cardiovascular events in patients with E-COPD. |
| first_indexed | 2024-03-12T21:26:17Z |
| format | Article |
| id | doaj.art-1bd26fcf882a4e05b00792eb8fde92ed |
| institution | Directory Open Access Journal |
| issn | 2432-6186 |
| language | English |
| last_indexed | 2024-03-12T21:26:17Z |
| publishDate | 2023-04-01 |
| publisher | Society of Tokyo Women's Medical University |
| record_format | Article |
| series | Tokyo Women's Medical University Journal |
| spelling | doaj.art-1bd26fcf882a4e05b00792eb8fde92ed2023-07-28T07:08:50ZengSociety of Tokyo Women's Medical UniversityTokyo Women's Medical University Journal2432-61862023-04-01advpub010.24488/twmuj.2022017twmujExacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary DiseaseMami Orimo0Tomohiro Akaba1Fumi Kobayashi2Azusa Miyoshi3Osamitsu Yagi4Hideki Katsura5Mitsuko Kondo6Estuko Tagaya7Department of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityDepartment of Respiratory Medicine, Tokyo Women's Medical UniversityBackground: Eosinophilia is often observed in patients with chronic obstructive pulmonary disease (COPD), but the influence of eosinophilia on the clinical outcomes of patients with COPD is unknown. This study aimed to evaluate the clinical characteristics of eosinophilic COPD (E-COPD) and define the effects of treatment with inhaled corticosteroids (ICS) on cardiovascular events in patients with E-COPD. Methods: We included 398 patients with COPD and classified them into two groups: E-COPD (blood eosinophil counts >300 cells/μL or >4%) and non-E-COPD. Patient characteristics and exacerbations between the two groups were compared and the effects of ICS on these variables were studied. Results: E-COPD patients (n = 196) experienced 4.49- and 6.13-time greater numbers of moderate and severe exacerbations, respectively, than non-E-COPD patients (n = 202). In the Cox proportional hazards analysis, higher eosinophil counts and lower pulmonary function values were significantly associated with moderate and severe exacerbations. Patients with E-COPD treated with ICS had fewer cardiovascular events than those treated without ICS (relative risk, 0.39; p = 0.011). Conclusion: These results suggest that eosinophilia may be associated with increased exacerbations of COPD and that treatment with ICS may be considered to reduce cardiovascular events in patients with E-COPD.https://www.jstage.jst.go.jp/article/twmuj/advpub/0/advpub_2022017/_pdf/-char/encardiovascular eventschronic obstructive pulmonary diseaseeosinophil countexacerbationinhaled corticosteroids |
| spellingShingle | Mami Orimo Tomohiro Akaba Fumi Kobayashi Azusa Miyoshi Osamitsu Yagi Hideki Katsura Mitsuko Kondo Estuko Tagaya Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease Tokyo Women's Medical University Journal cardiovascular events chronic obstructive pulmonary disease eosinophil count exacerbation inhaled corticosteroids |
| title | Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease |
| title_full | Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease |
| title_fullStr | Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease |
| title_short | Exacerbation and Cardiovascular Events in Eosinophilic Chronic Obstructive Pulmonary Disease |
| title_sort | exacerbation and cardiovascular events in eosinophilic chronic obstructive pulmonary disease |
| topic | cardiovascular events chronic obstructive pulmonary disease eosinophil count exacerbation inhaled corticosteroids |
| url | https://www.jstage.jst.go.jp/article/twmuj/advpub/0/advpub_2022017/_pdf/-char/en |
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