Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication

Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication

ABSTRACT Using multiple viral systems, and performing silencing approaches, overexpression approaches, and experiments in knockout cells, we report, for the first time, that interferon (IFN)-induced protein 44 (IFI44) positively affects virus production and negatively modulates innate immune respons...

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Bibliographic Details
Main Authors: Marta L. DeDiego, Aitor Nogales, Luis Martinez-Sobrido, David J. Topham
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
FKBP5
IFI44
IFN responses
antiviral responses
innate immunity
signaling transduction
Online Access:https://journals.asm.org/doi/10.1128/mBio.01839-19

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