Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis

Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis

Objectives: Synovitis plays an important role in knee osteoarthritis (KOA) pain. The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in fibroblast-like synoviocytes (FLSs) promotes KOA development. In this study, we aimed to investigate whether vanillic acid (VA), a monomer derive...

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Bibliographic Details
Main Authors: Zhenyuan Ma, Zhengquan Huang, Li Zhang, Xiaochen Li, Bo Xu, Yancheng Xiao, Xiaoqing Shi, Haosheng Zhang, Taiyang Liao, Peimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
vanillic acid
knee osteoarthritis
synovial inflammation
NLRP3 inflammasome
pain 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.599022/full

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