Physical Exercise Inhibits Inflammation and Microglial Activation
Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems that are known to regulate neuroinflammation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/7/691 |
| _version_ | 1797711081231089664 |
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| author | Onanong Mee-inta Zi-Wei Zhao Yu-Min Kuo |
| author_facet | Onanong Mee-inta Zi-Wei Zhao Yu-Min Kuo |
| author_sort | Onanong Mee-inta |
| collection | DOAJ |
| description | Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems that are known to regulate neuroinflammation and glial activation. Activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. The purpose of this review is to highlight the impacts of exercise on microglial activation. Possible mechanisms involved in exercise-modulated microglial activation are also discussed. Undoubtedly, more studies are needed in order to disclose the detailed mechanisms, but this approach offers therapeutic potential for improving the brain health of millions of aging people where pharmacological intervention has failed. |
| first_indexed | 2024-03-12T07:01:52Z |
| format | Article |
| id | doaj.art-1bd3eef5b6aa4b149925099efd873897 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:01:52Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1bd3eef5b6aa4b149925099efd8738972023-09-02T23:40:56ZengMDPI AGCells2073-44092019-07-018769110.3390/cells8070691cells8070691Physical Exercise Inhibits Inflammation and Microglial ActivationOnanong Mee-inta0Zi-Wei Zhao1Yu-Min Kuo2Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, TaiwanInstitute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, TaiwanInstitute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, TaiwanAccumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems that are known to regulate neuroinflammation and glial activation. Activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. The purpose of this review is to highlight the impacts of exercise on microglial activation. Possible mechanisms involved in exercise-modulated microglial activation are also discussed. Undoubtedly, more studies are needed in order to disclose the detailed mechanisms, but this approach offers therapeutic potential for improving the brain health of millions of aging people where pharmacological intervention has failed.https://www.mdpi.com/2073-4409/8/7/691neuroinflammationmyokinegrowth factoranti-inflammatoryantioxidantneurodegeneration |
| spellingShingle | Onanong Mee-inta Zi-Wei Zhao Yu-Min Kuo Physical Exercise Inhibits Inflammation and Microglial Activation Cells neuroinflammation myokine growth factor anti-inflammatory antioxidant neurodegeneration |
| title | Physical Exercise Inhibits Inflammation and Microglial Activation |
| title_full | Physical Exercise Inhibits Inflammation and Microglial Activation |
| title_fullStr | Physical Exercise Inhibits Inflammation and Microglial Activation |
| title_full_unstemmed | Physical Exercise Inhibits Inflammation and Microglial Activation |
| title_short | Physical Exercise Inhibits Inflammation and Microglial Activation |
| title_sort | physical exercise inhibits inflammation and microglial activation |
| topic | neuroinflammation myokine growth factor anti-inflammatory antioxidant neurodegeneration |
| url | https://www.mdpi.com/2073-4409/8/7/691 |
| work_keys_str_mv | AT onanongmeeinta physicalexerciseinhibitsinflammationandmicroglialactivation AT ziweizhao physicalexerciseinhibitsinflammationandmicroglialactivation AT yuminkuo physicalexerciseinhibitsinflammationandmicroglialactivation |