Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ level. The aim of this stu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-05-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/7/1/15 |
| _version_ | 1819058572571443200 |
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| author | Matthews D Geoffrey Hao Huming Smith Trudy J Panagiotopoulos Sianna Thomas Merlin C MacIsaac Richard J Jerums George Burrell Louise M Srivastava Piyush M |
| author_facet | Matthews D Geoffrey Hao Huming Smith Trudy J Panagiotopoulos Sianna Thomas Merlin C MacIsaac Richard J Jerums George Burrell Louise M Srivastava Piyush M |
| author_sort | Matthews D Geoffrey |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ level. The aim of this study was therefore to examine whether there was a correlation between resistance of the intrarenal arteries of the kidney and compliance of the left ventricle, as estimated by measurements of diastolic function, in subjects with type 2 diabetes.</p> <p>Methods</p> <p>We studied 167 unselected clinic patients with type 2 diabetes with a kidney duplex scan to estimate intrarenal vascular resistance, i.e. the resistance index (RI = peak systolic velocity-minimum diastolic velocity/peak systolic velocity) and a transthoracic echocardiogram (TTE) employing tissue doppler studies to document diastolic and systolic ventricular function.</p> <p>Results</p> <p>Renal RI was significantly higher in subjects with diastolic dysfunction (0.72 ± 0.05) when compared with those who had a normal TTE examination (0.66 ± 0.06, p < 0.01). Renal RI values were correlated with markers of diastolic dysfunction including the E/Vp ratio (r = 0.41, p < 0.001), left atrial area (r = 0.36, p < 0.001), the E/A ratio (r = 0.36, p < 0.001) and the E/E' ratio (r = 0.31, p < 0.001). These associations were independent of systolic function, hypertension, the presence and severity of chronic kidney disease, the use of renin-angiotensin inhibitors and other potentially confounding variables.</p> <p>Conclusion</p> <p>Increasing vascular resistance of the intrarenal arteries was associated with markers of diastolic dysfunction in subjects with type 2 diabetes. These findings are consistent with the hypothesis that vascular and cardiac stiffening in diabetes are manifestations of common pathophysiological mechanisms.</p> |
| first_indexed | 2024-12-21T13:57:20Z |
| format | Article |
| id | doaj.art-1bd4a7078b234d74997600bba9dfa69a |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-21T13:57:20Z |
| publishDate | 2008-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-1bd4a7078b234d74997600bba9dfa69a2022-12-21T19:01:29ZengBMCCardiovascular Diabetology1475-28402008-05-01711510.1186/1475-2840-7-15Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetesMatthews D GeoffreyHao HumingSmith Trudy JPanagiotopoulos SiannaThomas Merlin CMacIsaac Richard JJerums GeorgeBurrell Louise MSrivastava Piyush M<p>Abstract</p> <p>Background</p> <p>In comparison to the well established changes in compliance that occur at the large vessel level in diabetes, much less is known about the changes in compliance of the cardiovascular system at the end-organ level. The aim of this study was therefore to examine whether there was a correlation between resistance of the intrarenal arteries of the kidney and compliance of the left ventricle, as estimated by measurements of diastolic function, in subjects with type 2 diabetes.</p> <p>Methods</p> <p>We studied 167 unselected clinic patients with type 2 diabetes with a kidney duplex scan to estimate intrarenal vascular resistance, i.e. the resistance index (RI = peak systolic velocity-minimum diastolic velocity/peak systolic velocity) and a transthoracic echocardiogram (TTE) employing tissue doppler studies to document diastolic and systolic ventricular function.</p> <p>Results</p> <p>Renal RI was significantly higher in subjects with diastolic dysfunction (0.72 ± 0.05) when compared with those who had a normal TTE examination (0.66 ± 0.06, p < 0.01). Renal RI values were correlated with markers of diastolic dysfunction including the E/Vp ratio (r = 0.41, p < 0.001), left atrial area (r = 0.36, p < 0.001), the E/A ratio (r = 0.36, p < 0.001) and the E/E' ratio (r = 0.31, p < 0.001). These associations were independent of systolic function, hypertension, the presence and severity of chronic kidney disease, the use of renin-angiotensin inhibitors and other potentially confounding variables.</p> <p>Conclusion</p> <p>Increasing vascular resistance of the intrarenal arteries was associated with markers of diastolic dysfunction in subjects with type 2 diabetes. These findings are consistent with the hypothesis that vascular and cardiac stiffening in diabetes are manifestations of common pathophysiological mechanisms.</p>http://www.cardiab.com/content/7/1/15 |
| spellingShingle | Matthews D Geoffrey Hao Huming Smith Trudy J Panagiotopoulos Sianna Thomas Merlin C MacIsaac Richard J Jerums George Burrell Louise M Srivastava Piyush M Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes Cardiovascular Diabetology |
| title | Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| title_full | Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| title_fullStr | Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| title_full_unstemmed | Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| title_short | Association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| title_sort | association between intrarenal arterial resistance and diastolic dysfunction in type 2 diabetes |
| url | http://www.cardiab.com/content/7/1/15 |
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