Ocular toxoplasmosis: the influence of patient age

The influence of patient age on various features of ocular toxoplasmosis has been a subject of study for many years. The age at which Toxoplasma gondii infection occurs in different populations is related to socioeconomic factors and studies suggest that ocular toxoplasmosis is a more severe disease...

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Main Author: Gary N Holland
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2009-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200031
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author Gary N Holland
author_facet Gary N Holland
author_sort Gary N Holland
collection DOAJ
description The influence of patient age on various features of ocular toxoplasmosis has been a subject of study for many years. The age at which Toxoplasma gondii infection occurs in different populations is related to socioeconomic factors and studies suggest that ocular toxoplasmosis is a more severe disease at the extremes of age. The prevalence of ocular involvement is markedly different between individuals with congenital and those with post-natally acquired infections. Even among those with post-natally acquired infections, age influences the risk and timing of ocular involvement. The severity of toxoplasmic retinochoroiditis (in terms of lesion size, location and associated inflammation) is also affected by patient age at the time of initial infection or recurrence. The risk of recurrent toxoplasmic retinochoroiditis is influenced by age at the time of initial infection and age at most recent episode of active disease. Understanding of relationships between ocular toxoplasmosis and patient age is incomplete; evidence has often been indirect and in some cases conflicting. The influence of patient age on ocular toxoplasmosis should be studied in a systematic manner to provide a better understanding of disease mechanisms and to provide clinical information that can used to establish better strategies for disease treatment and prevention.
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spelling doaj.art-1bd56289219d4d7ab86643652a22f6d92023-08-02T09:32:19ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-03-01104235135710.1590/S0074-02762009000200031Ocular toxoplasmosis: the influence of patient ageGary N HollandThe influence of patient age on various features of ocular toxoplasmosis has been a subject of study for many years. The age at which Toxoplasma gondii infection occurs in different populations is related to socioeconomic factors and studies suggest that ocular toxoplasmosis is a more severe disease at the extremes of age. The prevalence of ocular involvement is markedly different between individuals with congenital and those with post-natally acquired infections. Even among those with post-natally acquired infections, age influences the risk and timing of ocular involvement. The severity of toxoplasmic retinochoroiditis (in terms of lesion size, location and associated inflammation) is also affected by patient age at the time of initial infection or recurrence. The risk of recurrent toxoplasmic retinochoroiditis is influenced by age at the time of initial infection and age at most recent episode of active disease. Understanding of relationships between ocular toxoplasmosis and patient age is incomplete; evidence has often been indirect and in some cases conflicting. The influence of patient age on ocular toxoplasmosis should be studied in a systematic manner to provide a better understanding of disease mechanisms and to provide clinical information that can used to establish better strategies for disease treatment and prevention.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200031ageelderlyeyerecurrenceretinochoroiditistoxoplasmosis
spellingShingle Gary N Holland
Ocular toxoplasmosis: the influence of patient age
Memorias do Instituto Oswaldo Cruz
age
elderly
eye
recurrence
retinochoroiditis
toxoplasmosis
title Ocular toxoplasmosis: the influence of patient age
title_full Ocular toxoplasmosis: the influence of patient age
title_fullStr Ocular toxoplasmosis: the influence of patient age
title_full_unstemmed Ocular toxoplasmosis: the influence of patient age
title_short Ocular toxoplasmosis: the influence of patient age
title_sort ocular toxoplasmosis the influence of patient age
topic age
elderly
eye
recurrence
retinochoroiditis
toxoplasmosis
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200031
work_keys_str_mv AT garynholland oculartoxoplasmosistheinfluenceofpatientage