Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy
This study reported our experience of the clinical characteristics of periparotid recurrence of nasopharyngeal carcinoma (NPC) after parotid-gland-sparing radiotherapy. We retrospectively reviewed the charts of 296 patients with NPC who underwent parotid-gland-sparing radiotherapy at the Tri-Service...
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| Format: | Article |
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Elsevier
2011-10-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664611000325 |
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| author | Deng-Shan Lin Yee-Min Jen Jih-Chin Lee Shao-Cheng Liu Yaoh-Shiang Lin |
| author_facet | Deng-Shan Lin Yee-Min Jen Jih-Chin Lee Shao-Cheng Liu Yaoh-Shiang Lin |
| author_sort | Deng-Shan Lin |
| collection | DOAJ |
| description | This study reported our experience of the clinical characteristics of periparotid recurrence of nasopharyngeal carcinoma (NPC) after parotid-gland-sparing radiotherapy. We retrospectively reviewed the charts of 296 patients with NPC who underwent parotid-gland-sparing radiotherapy at the Tri-Service General Hospital from 1998 to 2008. Eighty-three patients underwent three-dimensional conformal radiotherapy, and 205 patients underwent intensity-modulated radiotherapy; parotid glands were spared bilaterally in all patients. None of these patients had undergone previous radiotherapy or surgical treatment of the head and neck. Disease recurred in a spared parotid gland in three patients (1.04%). Two of these patients had undergone three-dimensional conformal radiotherapy and the third underwent intensity-modulated radiotherapy. All three patients had undergone parotidectomy. Adjuvant radiotherapy or concurrent chemoradiation was administered. One patient died of metastatic disease 26 months after diagnosis of recurrence; the others were well with no evidence of disease at 63 and 6 months after initial recurrence. Periparotid recurrence is an uncommon pattern of locoregional failure after parotid-gland-sparing radiotherapy for NPC. Early diagnosis and aggressive therapy for patients with periparotid recurrence may improve outcomes. |
| first_indexed | 2024-12-13T15:52:24Z |
| format | Article |
| id | doaj.art-1bd6d0b2bb3240fd8c2bce5ed02a01e1 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-13T15:52:24Z |
| publishDate | 2011-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-1bd6d0b2bb3240fd8c2bce5ed02a01e12022-12-21T23:39:25ZengElsevierJournal of the Formosan Medical Association0929-66462011-10-011101065566010.1016/j.jfma.2011.08.009Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapyDeng-Shan Lin0Yee-Min Jen1Jih-Chin Lee2Shao-Cheng Liu3Yaoh-Shiang Lin4Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanThis study reported our experience of the clinical characteristics of periparotid recurrence of nasopharyngeal carcinoma (NPC) after parotid-gland-sparing radiotherapy. We retrospectively reviewed the charts of 296 patients with NPC who underwent parotid-gland-sparing radiotherapy at the Tri-Service General Hospital from 1998 to 2008. Eighty-three patients underwent three-dimensional conformal radiotherapy, and 205 patients underwent intensity-modulated radiotherapy; parotid glands were spared bilaterally in all patients. None of these patients had undergone previous radiotherapy or surgical treatment of the head and neck. Disease recurred in a spared parotid gland in three patients (1.04%). Two of these patients had undergone three-dimensional conformal radiotherapy and the third underwent intensity-modulated radiotherapy. All three patients had undergone parotidectomy. Adjuvant radiotherapy or concurrent chemoradiation was administered. One patient died of metastatic disease 26 months after diagnosis of recurrence; the others were well with no evidence of disease at 63 and 6 months after initial recurrence. Periparotid recurrence is an uncommon pattern of locoregional failure after parotid-gland-sparing radiotherapy for NPC. Early diagnosis and aggressive therapy for patients with periparotid recurrence may improve outcomes.http://www.sciencedirect.com/science/article/pii/S0929664611000325nasopharyngeal carcinomaparotid-gland-sparing radiotherapyperiparotid recurrence |
| spellingShingle | Deng-Shan Lin Yee-Min Jen Jih-Chin Lee Shao-Cheng Liu Yaoh-Shiang Lin Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy Journal of the Formosan Medical Association nasopharyngeal carcinoma parotid-gland-sparing radiotherapy periparotid recurrence |
| title | Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy |
| title_full | Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy |
| title_fullStr | Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy |
| title_full_unstemmed | Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy |
| title_short | Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy |
| title_sort | recurrence of nasopharyngeal carcinoma in the parotid region after parotid gland sparing radiotherapy |
| topic | nasopharyngeal carcinoma parotid-gland-sparing radiotherapy periparotid recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S0929664611000325 |
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