Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid

Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid

Lysophosphatidic acid (LPA) is a promising biomarker candidate to screen for ovarian cancer (OC) and potentially stratify and treat patients according to disease stage. LPA is known to target the actin-binding protein gelsolin which is a key regulator of actin filament assembly. Previous studies hav...

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Bibliographic Details
Main Authors: Katharina Davoudian, Shayon Bhattacharya, Damien Thompson, Michael Thompson
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
ovarian cancer
lysophosphatidic acid
gelsolin
actin
lipid-protein interaction
predictive molecular modelling
Online Access:https://www.mdpi.com/2218-273X/13/9/1426

Internet

https://www.mdpi.com/2218-273X/13/9/1426

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