Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examin...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-03-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/66884 |
| _version_ | 1828108331018878976 |
|---|---|
| author | Kayla M Ferko Anna Blumenthal Chris B Martin Daria Proklova Alexander N Minos Lisa M Saksida Timothy J Bussey Ali R Khan Stefan Köhler |
| author_facet | Kayla M Ferko Anna Blumenthal Chris B Martin Daria Proklova Alexander N Minos Lisa M Saksida Timothy J Bussey Ali R Khan Stefan Köhler |
| author_sort | Kayla M Ferko |
| collection | DOAJ |
| description | Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. In the current study, we addressed this question by focussing on perceived visual similarities among subordinate exemplars of real-world categories. We hypothesized that these perceived similarities are reflected with highest fidelity in neural activity patterns downstream from inferotemporal regions, namely in perirhinal (PrC) and anterolateral entorhinal cortex (alErC) in the medial temporal lobe. To address this issue with functional magnetic resonance imaging (fMRI), we administered a modified 1-back task that required discrimination between category exemplars as well as categorization. Further, we obtained observer-specific ratings of perceived visual similarities, which predicted behavioural discrimination performance during scanning. As anticipated, we found that activity patterns in PrC and alErC predicted the structure of perceived visual similarity relationships among category exemplars, including its observer-specific component, with higher precision than any other VVS region. Our findings provide new evidence that subjective aspects of object perception that rely on fine-grained visual differentiation are reflected with highest fidelity in the medial temporal lobe. |
| first_indexed | 2024-04-11T10:45:13Z |
| format | Article |
| id | doaj.art-1bdad062c5e94aaeb548a559f2ba2ca7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:45:13Z |
| publishDate | 2022-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1bdad062c5e94aaeb548a559f2ba2ca72022-12-22T04:29:04ZengeLife Sciences Publications LtdeLife2050-084X2022-03-011110.7554/eLife.66884Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precisionKayla M Ferko0https://orcid.org/0000-0003-4362-7295Anna Blumenthal1https://orcid.org/0000-0002-8768-0189Chris B Martin2https://orcid.org/0000-0002-7014-4371Daria Proklova3Alexander N Minos4Lisa M Saksida5Timothy J Bussey6Ali R Khan7https://orcid.org/0000-0002-0760-8647Stefan Köhler8https://orcid.org/0000-0003-1905-6453Brain and Mind Institute, University of Western Ontario, London, Canada; Robarts Research Institute Schulich School of Medicine and Dentistry, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, Canada; Cervo Brain Research Center, University of Laval, Quebec, CanadaDepartment of Psychology, Florida State University, Tallahassee, United StatesBrain and Mind Institute, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, Canada; Robarts Research Institute Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, Canada; Robarts Research Institute Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, Canada; Robarts Research Institute Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; School of Biomedical Engineering, University of Western Ontario, London, Canada; Department of Medical Biophysics, University of Western Ontario, London, CanadaBrain and Mind Institute, University of Western Ontario, London, Canada; Department of Psychology, University of Western Ontario, London, CanadaVision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. In the current study, we addressed this question by focussing on perceived visual similarities among subordinate exemplars of real-world categories. We hypothesized that these perceived similarities are reflected with highest fidelity in neural activity patterns downstream from inferotemporal regions, namely in perirhinal (PrC) and anterolateral entorhinal cortex (alErC) in the medial temporal lobe. To address this issue with functional magnetic resonance imaging (fMRI), we administered a modified 1-back task that required discrimination between category exemplars as well as categorization. Further, we obtained observer-specific ratings of perceived visual similarities, which predicted behavioural discrimination performance during scanning. As anticipated, we found that activity patterns in PrC and alErC predicted the structure of perceived visual similarity relationships among category exemplars, including its observer-specific component, with higher precision than any other VVS region. Our findings provide new evidence that subjective aspects of object perception that rely on fine-grained visual differentiation are reflected with highest fidelity in the medial temporal lobe.https://elifesciences.org/articles/66884medial temporal lobeventral visual pathwayvisual discriminationfMRIobject recognition |
| spellingShingle | Kayla M Ferko Anna Blumenthal Chris B Martin Daria Proklova Alexander N Minos Lisa M Saksida Timothy J Bussey Ali R Khan Stefan Köhler Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision eLife medial temporal lobe ventral visual pathway visual discrimination fMRI object recognition |
| title | Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| title_full | Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| title_fullStr | Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| title_full_unstemmed | Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| title_short | Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| title_sort | activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision |
| topic | medial temporal lobe ventral visual pathway visual discrimination fMRI object recognition |
| url | https://elifesciences.org/articles/66884 |
| work_keys_str_mv | AT kaylamferko activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT annablumenthal activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT chrisbmartin activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT dariaproklova activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT alexandernminos activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT lisamsaksida activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT timothyjbussey activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT alirkhan activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision AT stefankohler activityinperirhinalandentorhinalcortexpredictsperceivedvisualsimilaritiesamongcategoryexemplarswithhighestprecision |