Chitosan-Based Nanocarriers for Delivery of Remdesivir
Stable multicomponent capsules for the delivery of remdesivir (Veklury<sup>®</sup>) are produced through subsequent electrostatic adsorption of oppositely charged components on oil emulsion droplets. For the first time, the encapsulation and release of the medicine Veklury<sup>®<...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Scientia Pharmaceutica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-0532/91/3/37 |
| _version_ | 1827723668271136768 |
|---|---|
| author | Viktoria Milkova Kamelia Kamburova Petar Martinov Neli Vilhelmova-Ilieva Viktor Rashev |
| author_facet | Viktoria Milkova Kamelia Kamburova Petar Martinov Neli Vilhelmova-Ilieva Viktor Rashev |
| author_sort | Viktoria Milkova |
| collection | DOAJ |
| description | Stable multicomponent capsules for the delivery of remdesivir (Veklury<sup>®</sup>) are produced through subsequent electrostatic adsorption of oppositely charged components on oil emulsion droplets. For the first time, the encapsulation and release of the medicine Veklury<sup>®</sup> from polymer capsules was reported. In this study, the effect of the physicochemical properties of chitosan on the size and stability of the produced structures is investigated, on the loaded amount of drug and on the kinetics of drug release in conditions close to the physiological ones. Microbiological studies of the capsules and their constituents were performed via in vitro assays against HCT-8 cell lines and human coronavirus HCoV-OC43. A detailed analysis was performed on the influence of the properties of produced capsules on cytotoxicity against the chosen cell line, as well as their effect on the replication cycle of the virus, the virucidal activity of the samples against the viability of the extracellular virions, and their effect on viral adsorption on the cell membrane. |
| first_indexed | 2024-03-10T22:03:02Z |
| format | Article |
| id | doaj.art-1bdbe3a0dbc84d4395648036f1e77ddd |
| institution | Directory Open Access Journal |
| issn | 0036-8709 2218-0532 |
| language | English |
| last_indexed | 2024-03-10T22:03:02Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-1bdbe3a0dbc84d4395648036f1e77ddd2023-11-19T12:52:11ZengMDPI AGScientia Pharmaceutica0036-87092218-05322023-08-019133710.3390/scipharm91030037Chitosan-Based Nanocarriers for Delivery of RemdesivirViktoria Milkova0Kamelia Kamburova1Petar Martinov2Neli Vilhelmova-Ilieva3Viktor Rashev4Institute of Physical Chemistry “Acad. R. Kaicshew”, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaInstitute of Physical Chemistry “Acad. R. Kaicshew”, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaInstitute of Physical Chemistry “Acad. R. Kaicshew”, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaStable multicomponent capsules for the delivery of remdesivir (Veklury<sup>®</sup>) are produced through subsequent electrostatic adsorption of oppositely charged components on oil emulsion droplets. For the first time, the encapsulation and release of the medicine Veklury<sup>®</sup> from polymer capsules was reported. In this study, the effect of the physicochemical properties of chitosan on the size and stability of the produced structures is investigated, on the loaded amount of drug and on the kinetics of drug release in conditions close to the physiological ones. Microbiological studies of the capsules and their constituents were performed via in vitro assays against HCT-8 cell lines and human coronavirus HCoV-OC43. A detailed analysis was performed on the influence of the properties of produced capsules on cytotoxicity against the chosen cell line, as well as their effect on the replication cycle of the virus, the virucidal activity of the samples against the viability of the extracellular virions, and their effect on viral adsorption on the cell membrane.https://www.mdpi.com/2218-0532/91/3/37chitosanremdesivirVeklury<sup>®</sup>aptamerencapsulationdrug release |
| spellingShingle | Viktoria Milkova Kamelia Kamburova Petar Martinov Neli Vilhelmova-Ilieva Viktor Rashev Chitosan-Based Nanocarriers for Delivery of Remdesivir Scientia Pharmaceutica chitosan remdesivir Veklury<sup>®</sup> aptamer encapsulation drug release |
| title | Chitosan-Based Nanocarriers for Delivery of Remdesivir |
| title_full | Chitosan-Based Nanocarriers for Delivery of Remdesivir |
| title_fullStr | Chitosan-Based Nanocarriers for Delivery of Remdesivir |
| title_full_unstemmed | Chitosan-Based Nanocarriers for Delivery of Remdesivir |
| title_short | Chitosan-Based Nanocarriers for Delivery of Remdesivir |
| title_sort | chitosan based nanocarriers for delivery of remdesivir |
| topic | chitosan remdesivir Veklury<sup>®</sup> aptamer encapsulation drug release |
| url | https://www.mdpi.com/2218-0532/91/3/37 |
| work_keys_str_mv | AT viktoriamilkova chitosanbasednanocarriersfordeliveryofremdesivir AT kameliakamburova chitosanbasednanocarriersfordeliveryofremdesivir AT petarmartinov chitosanbasednanocarriersfordeliveryofremdesivir AT nelivilhelmovailieva chitosanbasednanocarriersfordeliveryofremdesivir AT viktorrashev chitosanbasednanocarriersfordeliveryofremdesivir |