5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2 Signaling Pathway

5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2 Signaling Pathway

Sodium ferrous citrate (SFC) is involved in the metabolism of 5-aminolevulinic acid (5-ALA) and enhances its anti-inflammatory effects. The effects of 5-ALA/SFC on inflammation in rats with endotoxin-induced uveitis (EIU) have yet to be elucidated. In this study, during lipopolysaccharide injection,...

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Bibliographic Details
Main Authors: Yuya Otaka, Kazutaka Kanai, Arisa Mori, Daiki Okada, Noriaki Nagai, Yohei Yamashita, Yoichiro Ichikawa, Kazuki Tajima
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
HO-1
lipopolysaccharide
Nrf2
NF-κB
sodium ferrous citrate
uveitis
Online Access:https://www.mdpi.com/1422-0067/24/10/8653

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