Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells

Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells

ABSTRACT Most alphaviruses are transmitted by mosquito vectors and infect a wide range of vertebrate hosts, with a few exceptions. Eilat virus (EILV) in this genus is characterized by a host range restricted to mosquitoes. Its chimeric viruses have been developed as safe and effective vaccine candid...

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Bibliographic Details
Main Authors: Lu Tan, Yiwen Zhang, Dal Young Kim, Runsheng Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Eilat virus
alphaviruses
antiviral responses
chimeric viruses
mosquito cells
virus-vector interactions
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03613-22

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