EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

Abstract Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis. Here we find that multiple viral envelope proteins, including Hepatitis C Virus (HCV)-E2,...

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Bibliographic Details
Main Authors:	Qiu Pan, Yan Xie, Ying Zhang, Xinqi Guo, Jing Wang, Min Liu, Xiao-Lian Zhang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-44960-6

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