Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation

Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation

Summary: UHRF1 is a key regulator in DNA methylation maintenance. It binds histone H3K9me2/3 and hemi-methylated DNA and recruits DNMT1 to DNA replication forks during S phase. However, the regulatory mechanism of hemi-methylated DNA binding activity of UHRF1 remains unknown. In this study, we revea...

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Bibliographic Details
Main Authors: Ja Young Hahm, Jin Woo Park, Joo-Young Kang, Junyoung Park, Chul-Hong Kim, Ji-Young Kim, Nam-Chul Ha, Jung-Woong Kim, Sang-Beom Seo
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
UHRF1
PCAF
acetylation
DNA methylation
HDAC1
hemi-methylated DNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309396

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