Investigation of the Flexibility of Protein Kinases Implicated in the Pathology of Alzheimer’s Disease

Investigation of the Flexibility of Protein Kinases Implicated in the Pathology of Alzheimer’s Disease

The pathological characteristics of Alzheimer’s Disease (AD) have been linked to the activity of three particular kinases—Glycogen Synthase Kinase 3β (GSK3β), Cyclin-Dependent Kinase 5 (CDK5) and Extracellular-signal Regulated Kinase 2 (ERK2). As a consequence, the design of selective, potent and d...

Full description

Bibliographic Details
Main Authors:	Michael P. Mazanetz, Charles A. Laughton, Peter M. Fischer
Format:	Article
Language:	English
Published:	MDPI AG 2014-06-01
Series:	Molecules
Subjects:	active site pressurisation kinase structure-based drug design protein flexibility molecular dynamics
Online Access:	http://www.mdpi.com/1420-3049/19/7/9134

Similar Items

Modified femoral pressuriser generates a longer lasting high pressure during cement pressurisation
by: Kjellson Fred, et al.
Published: (2011-10-01)

METROLOGICAL BEHAVIOUR OF BULK WATER METERS UNDER DIVERSE INSTALLATION CONFIGURATIONS
by: Carmen V. Palau, et al.
Published: (2018-12-01)

Stop using the flotation technique and start weighing salbutamol pressurised metered-dose inhalers without dose counters
by: Ermindo R. Di Paolo, et al.
Published: (2015-07-01)

Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery
by: Gennady Verkhivker, et al.
Published: (2013-11-01)

Kinase drug discovery /
by: Ward, Richard A., et al.
Published: (c201)

Real-Time Behaviour of Dredged Slurry Treated by Air-Booster Vacuum Consolidation
by: Kang Yao, et al.
Published: (2023-03-01)

In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
by: Zarko Gagic, et al.
Published: (2020-01-01)

Thermo-economic assessment of salt hydrate-based thermochemical heat transformer system: heat upgrade for matching domestic hot water production
by: Li, Wei, et al.
Published: (2023)

UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) with oxaliplatin for colorectal cancer peritoneal metastases (NCT03868228)
by: Kyle Peter, et al.
Published: (2023-09-01)

The Relationship Between Clinical Trial Participation and Inhaler Technique Errors in Asthma and COPD Patients
by: Perumal R, et al.
Published: (2020-06-01)

DESIDS: An Integrated Decision Support System for the Planning, Analysis, Management and Rehabilitation of Pressurised Irrigation Distribution Systems
by: Abdelouahid Fouial, et al.
Published: (2021-05-01)

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors
by: Giulio Poli, et al.
Published: (2018-01-01)

Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy
by: Saleha Anwar, et al.
Published: (2020-05-01)

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
by: Gabriella O Estevam, et al.
Published: (2025-02-01)

A complementary combination of delivery device and drug formulation for inhalation therapy in preschool children
by: KG Schüepp, et al.
Published: (2004-04-01)

Development and Test of an Equipment to Measure Residual Strain Inside Pipes Using the Hole-Drilling Method
by: Luiz Leite da Silva, et al.

Impact of Educational Programme on Inhalational Device Usage Techniques among the Patients Suffering from Asthma
by: S RAJESH KUMAR JAIN
Published: (2021-11-01)

GPS 5.0: An Update on the Prediction of Kinase-specific Phosphorylation Sites in Proteins
by: Chenwei Wang, et al.
Published: (2020-02-01)

The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
by: Sara Amiri, et al.
Published: (2020-03-01)

Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review
by: Isabela Marie Fernandes Silva, et al.
Published: (2024-10-01)

Investigating the Mechanism of Inhibition of Cyclin-Dependent Kinase 6 Inhibitory Potential by Selonsertib: Newer Insights Into Drug Repurposing
by: Mohammad Hassan Baig, et al.
Published: (2022-05-01)

Editorial: Recent advances in the research and development of kinase-inhibitory anticancer molecules
by: Ahmed A. Al-Karmalawy, et al.
Published: (2023-11-01)

Sparking signals : kinases as molecular signaltransducers and pharmacological drug targets in inflammation /
by: Baier, Gottfried
Published: (2008)

Allosteric regulation of kinase activity in living cells
by: Shivani Sujay Godbole, et al.
Published: (2023-11-01)

Battery Earth: using the subsurface at Boulby underground laboratory to investigate energy storage technologies
by: Katherine A. Daniels, et al.
Published: (2023-10-01)

The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
by: Sara Amiri, et al.
Published: (2020-03-01)

Computational methods for analysis and inference of kinase/inhibitor relationships
by: Fabrizio eFerrè, et al.
Published: (2014-06-01)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation
by: Bullock, A, et al.
Published: (2009)

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents
by: Laura Llorach-Pares, et al.
Published: (2017-11-01)

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study
by: Eleanor L. Atkinson, et al.
Published: (2021-03-01)

Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations
by: Caio Bezerra Machado, et al.
Published: (2021-10-01)

Novel pyrrolo[2,3-d]pyrimidine derivatives as multi-kinase inhibitors with VEGFR-2 selectivity
by: AbdulAziz A. Alotaibi, et al.
Published: (2023-09-01)

Abl family kinases in development and disease /
by: Koleske, Anthony J.
Published: (2006)

A Conserved Structural Role for the Walker-A Lysine in P-Loop Containing Kinases
by: Fatlum Hajredini, et al.
Published: (2021-10-01)

Dynamics of human protein kinase Aurora A linked to drug selectivity
by: Warintra Pitsawong, et al.
Published: (2018-06-01)

Analysis of Transient Interactions between a PWR Nuclear Power Plant and a Faulted Electricity Grid
by: Vineet Vajpayee, et al.
Published: (2021-03-01)

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era
by: Piers J. Naughton, et al.
Published: (2021-09-01)

Valorisation, Green Extraction Development, and Metabolomic Analysis of Wild Artichoke By-Product Using Pressurised Liquid Extraction UPLC–HRMS and Multivariate Data Analysis
by: Stefania Pagliari, et al.
Published: (2022-10-01)

Effect of Temperatures on Polyphenols during Extraction
by: Anila Antony, et al.
Published: (2022-02-01)

Binding of the antibacterial drug clofoctol and analogues to the Cdc7/Dbf4 kinase complex. A computational study
by: Gérard Vergoten, et al.
Published: (2021-09-01)