Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria

Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria

Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria. The safe-for-human-use hydroxyquinoline analog ionophore...

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Bibliographic Details
Main Authors: David M. P. De Oliveira, Bernhard Keller, Andrew J. Hayes, Cheryl-Lynn Y. Ong, Nichaela Harbison-Price, Ibrahim M. El-Deeb, Gen Li, Nadia Keller, Lisa Bohlmann, Stephan Brouwer, Andrew G. Turner, Amanda J. Cork, Thomas R. Jones, David L. Paterson, Alastair G. McEwan, Mark R. Davies, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
antimicrobial resistance
polymyxins
PBT2
ionophores
Gram-positive bacteria
Online Access:https://www.mdpi.com/2079-6382/11/4/449

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