Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
With a rapidly aging population, the prevalence of hypertension in adults continues to rise, placing a substantial and escalating social and economic burden. Ilex hainanensis Merr. is commonly used as a folk remedy for treating hypertension, dyslipidemia, and inflammation in China. This systematic r...
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00424/full |
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| author | Xiaochen Yang Guoyan Yang Weina Li Yun Zhang Jie Wang |
| author_facet | Xiaochen Yang Guoyan Yang Weina Li Yun Zhang Jie Wang |
| author_sort | Xiaochen Yang |
| collection | DOAJ |
| description | With a rapidly aging population, the prevalence of hypertension in adults continues to rise, placing a substantial and escalating social and economic burden. Ilex hainanensis Merr. is commonly used as a folk remedy for treating hypertension, dyslipidemia, and inflammation in China. This systematic review aims to evaluate current evidence for the therapeutic effect of Ilex hainanensis Merr. extract (EIH) on essential hypertension. Six electronic databases (Pubmed, MEDLINE, The Cochrane Central Register of Controlled Trials, Chinese Scientific Journals Database, Wanfang and CNKI) were searched to identify eligible randomized controlled trials (RCTs) relevant to EIH on essential hypertension up to Jan 2018. Six RCTs including 772 participants met eligibility criteria. Methodological quality of the trials was generally low. Meta-analysis showed that EIH demonstrated a beneficial effect for lowering systolic and diastolic blood pressure (SBP/DBP), left ventricular mass (LVM) in participants with essential hypertension. There was no significant difference between EIH and antihypertensive drugs in SBP (WMD: −0.44 [−2.30, 1.43]; P = 0.65), DBP (WMD: WMD: −0.02 [−1.13, 1.09]; P = 0.98) and LVM (WMD: −1.36 [−4.99, 2.26]; P = 0.46). Moreover, one trial showed that EIH combined with antihypertensive drugs was more effective in lowering blood pressure than those antihypertensive drugs used alone. However, the findings were limited by the small sample sizes, duration and low methodological quality of the trials. This is the first systematic review of EIH on essential hypertension. More rigorous RCTs with high quality are still needed to prove the effectiveness and safety of EIH and its preparations for essential hypertension. |
| first_indexed | 2024-12-22T07:50:00Z |
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| language | English |
| last_indexed | 2024-12-22T07:50:00Z |
| publishDate | 2018-05-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-1be7bb0f193641cdab3c953c17f9df992022-12-21T18:33:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-05-01910.3389/fphar.2018.00424368551Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsXiaochen Yang0Guoyan Yang1Weina Li2Yun Zhang3Jie Wang4Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCentre for Complementary Medicine Research, University of Western Sydney, Sydney, NSW, AustraliaDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaWith a rapidly aging population, the prevalence of hypertension in adults continues to rise, placing a substantial and escalating social and economic burden. Ilex hainanensis Merr. is commonly used as a folk remedy for treating hypertension, dyslipidemia, and inflammation in China. This systematic review aims to evaluate current evidence for the therapeutic effect of Ilex hainanensis Merr. extract (EIH) on essential hypertension. Six electronic databases (Pubmed, MEDLINE, The Cochrane Central Register of Controlled Trials, Chinese Scientific Journals Database, Wanfang and CNKI) were searched to identify eligible randomized controlled trials (RCTs) relevant to EIH on essential hypertension up to Jan 2018. Six RCTs including 772 participants met eligibility criteria. Methodological quality of the trials was generally low. Meta-analysis showed that EIH demonstrated a beneficial effect for lowering systolic and diastolic blood pressure (SBP/DBP), left ventricular mass (LVM) in participants with essential hypertension. There was no significant difference between EIH and antihypertensive drugs in SBP (WMD: −0.44 [−2.30, 1.43]; P = 0.65), DBP (WMD: WMD: −0.02 [−1.13, 1.09]; P = 0.98) and LVM (WMD: −1.36 [−4.99, 2.26]; P = 0.46). Moreover, one trial showed that EIH combined with antihypertensive drugs was more effective in lowering blood pressure than those antihypertensive drugs used alone. However, the findings were limited by the small sample sizes, duration and low methodological quality of the trials. This is the first systematic review of EIH on essential hypertension. More rigorous RCTs with high quality are still needed to prove the effectiveness and safety of EIH and its preparations for essential hypertension.http://journal.frontiersin.org/article/10.3389/fphar.2018.00424/fullIlex hainanensis Merr.hypertensiontraditional Chinese medicinesystematic reviewmeta-analysis |
| spellingShingle | Xiaochen Yang Guoyan Yang Weina Li Yun Zhang Jie Wang Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Frontiers in Pharmacology Ilex hainanensis Merr. hypertension traditional Chinese medicine systematic review meta-analysis |
| title | Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Therapeutic Effect of Ilex hainanensis Merr. Extract on Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | therapeutic effect of ilex hainanensis merr extract on essential hypertension a systematic review and meta analysis of randomized controlled trials |
| topic | Ilex hainanensis Merr. hypertension traditional Chinese medicine systematic review meta-analysis |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00424/full |
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