Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures

Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures

Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant population of epilepsy patients, non-convulsive seizures (ncSZ) are observed. The...

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Bibliographic Details
Main Authors: Pascal Bielefeld, Marijn Schouten, Guido M. Meijer, Marit J. Breuk, Karlijne Geijtenbeek, Sedef Karayel, Alisa Tiaglik, Anna H. Vuuregge, Ruth A.L. Willems, Diede Witkamp, Paul J. Lucassen, Juan M. Encinas, Carlos P. Fitzsimons
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
non-convulsive seizures
kainic acid
adult hippocampal neurogenesis
neural stem cell fate
microRNA
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00031/full

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