Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension
Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms. While inorganic nitrite and nitrate are now recognized as relevant sources of NO after the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-08-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231715000609 |
| _version_ | 1811207025039769600 |
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| author | Jefferson H. Amaral Graziele C. Ferreira Lucas C. Pinheiro Marcelo F. Montenegro Jose E. Tanus-Santos |
| author_facet | Jefferson H. Amaral Graziele C. Ferreira Lucas C. Pinheiro Marcelo F. Montenegro Jose E. Tanus-Santos |
| author_sort | Jefferson H. Amaral |
| collection | DOAJ |
| description | Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms. While inorganic nitrite and nitrate are now recognized as relevant sources of NO after their bioactivation by enzymatic and non-enzymatic pathways, thus lowering blood pressure, mounting evidence suggests that sodium nitrite also exerts antioxidant effects. Here we show for the first time that sodium nitrite exerts consistent systemic and vascular antioxidant and antihypertensive effects in the deoxycorticosterone-salt (DOCA-salt) hypertension model. This is particularly important because increased oxidative stress plays a major role in the DOCA-salt hypertension model, which is less dependent on activation of the renin-angiotensin system than other hypertension models. Indeed, antihypertensive effects of oral nitrite were associated with increased plasma nitrite and nitrate concentrations, and completely blunted hypertension-induced increases in plasma 8-isoprostane and lipid peroxide levels, in vascular reactive oxygen species, in vascular NADPH oxidase activity, and in vascular xanthine oxidoreductase activity. Together, these findings provide evidence that the oral administration of sodium nitrite consistently decreases the blood pressure in association with major antioxidant effects in experimental hypertension. Keywords: Nitrite, Hypertension, DOCA-salt, Oxidative stress, Nitric oxide |
| first_indexed | 2024-04-12T03:56:52Z |
| format | Article |
| id | doaj.art-1bea818e60884545a92690e8a3cbf9a7 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-12T03:56:52Z |
| publishDate | 2015-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-1bea818e60884545a92690e8a3cbf9a72022-12-22T03:48:48ZengElsevierRedox Biology2213-23172015-08-015340346Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertensionJefferson H. Amaral0Graziele C. Ferreira1Lucas C. Pinheiro2Marcelo F. Montenegro3Jose E. Tanus-Santos4Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, BrazilDepartment of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, BrazilCorresponding author.; Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, BrazilHypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms. While inorganic nitrite and nitrate are now recognized as relevant sources of NO after their bioactivation by enzymatic and non-enzymatic pathways, thus lowering blood pressure, mounting evidence suggests that sodium nitrite also exerts antioxidant effects. Here we show for the first time that sodium nitrite exerts consistent systemic and vascular antioxidant and antihypertensive effects in the deoxycorticosterone-salt (DOCA-salt) hypertension model. This is particularly important because increased oxidative stress plays a major role in the DOCA-salt hypertension model, which is less dependent on activation of the renin-angiotensin system than other hypertension models. Indeed, antihypertensive effects of oral nitrite were associated with increased plasma nitrite and nitrate concentrations, and completely blunted hypertension-induced increases in plasma 8-isoprostane and lipid peroxide levels, in vascular reactive oxygen species, in vascular NADPH oxidase activity, and in vascular xanthine oxidoreductase activity. Together, these findings provide evidence that the oral administration of sodium nitrite consistently decreases the blood pressure in association with major antioxidant effects in experimental hypertension. Keywords: Nitrite, Hypertension, DOCA-salt, Oxidative stress, Nitric oxidehttp://www.sciencedirect.com/science/article/pii/S2213231715000609 |
| spellingShingle | Jefferson H. Amaral Graziele C. Ferreira Lucas C. Pinheiro Marcelo F. Montenegro Jose E. Tanus-Santos Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension Redox Biology |
| title | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension |
| title_full | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension |
| title_fullStr | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension |
| title_full_unstemmed | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension |
| title_short | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension |
| title_sort | consistent antioxidant and antihypertensive effects of oral sodium nitrite in doca salt hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S2213231715000609 |
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