Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients
Abstract Introduction Inflammation seems to play a critical role in the development and progression of numerous cancers. Peripheral blood leukocyte count is an easily assessable parameter of systemic inflammatory response. Objective The aim of this study was to investigate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2017-01-01
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| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1587318 |
| _version_ | 1819152671049777152 |
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| author | Saurabh Bobdey Balasubramaniam Ganesh Prabhashankar Mishra Aanchal Jain |
| author_facet | Saurabh Bobdey Balasubramaniam Ganesh Prabhashankar Mishra Aanchal Jain |
| author_sort | Saurabh Bobdey |
| collection | DOAJ |
| description | Abstract
Introduction Inflammation seems to play a critical role in the development and progression of numerous cancers. Peripheral blood leukocyte count is an easily assessable parameter of systemic inflammatory response.
Objective The aim of this study was to investigate whether the pretreatment leukocyte counts can predict the prognosis of patients with oral cavity cancer.
Methods Medical records of 471 oral cavity cancer patients diagnosed between January 2007 and December 2008 were retrospectively analyzed. Receiver operating characteristic curve analysis and Cox proportional hazards analyses were applied to evaluate the associations of leukocyte counts with overall survival.
Results The overall five year's survival of the cohort was found to be 49.4%. On univariate analysis, elevated monocyte count (≥500/mm3) and neutrophil-to-lymphocyte ratio (NLR) (>2.38) were associated with poor overall survival (OS) (p = 0.001 and 0.000, respectively). Multivariate Cox proportional hazard analysis showed that higher monocyte and NLR levels were significant independent predictors of worse OS (HR = 1.385, 95% CI = 1.049 - 1.829; p < 0.05 and HR = 1.392, 95% CI = 1.045 - 1.855; p < 0.05, respectively). The advanced overall stage and lymph nodal involvement were also independent indicators for poor OS.
Conclusions Higher pretreatment monocyte and NLR levels are independent predictors of poor prognosis for patients with oral cavity cancer. Thus, these easily accessed variables can serve as a potent marker to predict the outcomes of oral cancer patients. |
| first_indexed | 2024-12-22T14:52:59Z |
| format | Article |
| id | doaj.art-1bec15717ee142eca84d45561cf5edcc |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-12-22T14:52:59Z |
| publishDate | 2017-01-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-1bec15717ee142eca84d45561cf5edcc2022-12-21T18:22:16ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642017-01-012101212710.1055/s-0036-1587318Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer PatientsSaurabh Bobdey0Balasubramaniam Ganesh1Prabhashankar Mishra2Aanchal Jain3Department of Medical Records, Biostatistics and Epidemiology, Tata Memorial Hospital Parel, Mumbai, IndiaDepartment of Medical Records, Biostatistics and Epidemiology, Tata Memorial Hospital Parel, Mumbai, IndiaDepartment of Medical Records, Biostatistics and Epidemiology, Tata Memorial Hospital Parel, Mumbai, IndiaDepartment of Medical Records, Biostatistics and Epidemiology, Tata Memorial Hospital Parel, Mumbai, IndiaAbstract Introduction Inflammation seems to play a critical role in the development and progression of numerous cancers. Peripheral blood leukocyte count is an easily assessable parameter of systemic inflammatory response. Objective The aim of this study was to investigate whether the pretreatment leukocyte counts can predict the prognosis of patients with oral cavity cancer. Methods Medical records of 471 oral cavity cancer patients diagnosed between January 2007 and December 2008 were retrospectively analyzed. Receiver operating characteristic curve analysis and Cox proportional hazards analyses were applied to evaluate the associations of leukocyte counts with overall survival. Results The overall five year's survival of the cohort was found to be 49.4%. On univariate analysis, elevated monocyte count (≥500/mm3) and neutrophil-to-lymphocyte ratio (NLR) (>2.38) were associated with poor overall survival (OS) (p = 0.001 and 0.000, respectively). Multivariate Cox proportional hazard analysis showed that higher monocyte and NLR levels were significant independent predictors of worse OS (HR = 1.385, 95% CI = 1.049 - 1.829; p < 0.05 and HR = 1.392, 95% CI = 1.045 - 1.855; p < 0.05, respectively). The advanced overall stage and lymph nodal involvement were also independent indicators for poor OS. Conclusions Higher pretreatment monocyte and NLR levels are independent predictors of poor prognosis for patients with oral cavity cancer. Thus, these easily accessed variables can serve as a potent marker to predict the outcomes of oral cancer patients.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1587318oral cancerprognosissurvivalmonocyteneutrophil-to-lymphocyte ratio |
| spellingShingle | Saurabh Bobdey Balasubramaniam Ganesh Prabhashankar Mishra Aanchal Jain Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients International Archives of Otorhinolaryngology oral cancer prognosis survival monocyte neutrophil-to-lymphocyte ratio |
| title | Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients |
| title_full | Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients |
| title_fullStr | Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients |
| title_full_unstemmed | Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients |
| title_short | Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients |
| title_sort | role of monocyte count and neutrophil to lymphocyte ratio in survival of oral cancer patients |
| topic | oral cancer prognosis survival monocyte neutrophil-to-lymphocyte ratio |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1587318 |
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