First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal.
Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first d...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4927072?pdf=render |
| _version_ | 1819204029924769792 |
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| author | Amadou Diop Bissoume Sambe-Ba Abdoulaye Seck Mouhamadou Lamine Dia Lassina Gadi Timbiné Aïssatou Ameth Niang El Hadji Momar Ndiaye Mouhamadou Abdoulaye Sonko Abdoul Aziz Wane Raymond Bercion Ousmane Ndiaye Moussa Fafa Cissé Amy Gassama-Sow |
| author_facet | Amadou Diop Bissoume Sambe-Ba Abdoulaye Seck Mouhamadou Lamine Dia Lassina Gadi Timbiné Aïssatou Ameth Niang El Hadji Momar Ndiaye Mouhamadou Abdoulaye Sonko Abdoul Aziz Wane Raymond Bercion Ousmane Ndiaye Moussa Fafa Cissé Amy Gassama-Sow |
| author_sort | Amadou Diop |
| collection | DOAJ |
| description | Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR. All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL). blaOXA-1, blaSHV-1, blaTEM-1, blaCTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. blaCTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella. |
| first_indexed | 2024-12-23T04:29:19Z |
| format | Article |
| id | doaj.art-1bed95e66fce48aeae36ae49df4a11d7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T04:29:19Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1bed95e66fce48aeae36ae49df4a11d72022-12-21T18:00:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015768310.1371/journal.pone.0157683First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal.Amadou DiopBissoume Sambe-BaAbdoulaye SeckMouhamadou Lamine DiaLassina Gadi TimbinéAïssatou Ameth NiangEl Hadji Momar NdiayeMouhamadou Abdoulaye SonkoAbdoul Aziz WaneRaymond BercionOusmane NdiayeMoussa Fafa CisséAmy Gassama-SowNosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR. All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL). blaOXA-1, blaSHV-1, blaTEM-1, blaCTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. blaCTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella.http://europepmc.org/articles/PMC4927072?pdf=render |
| spellingShingle | Amadou Diop Bissoume Sambe-Ba Abdoulaye Seck Mouhamadou Lamine Dia Lassina Gadi Timbiné Aïssatou Ameth Niang El Hadji Momar Ndiaye Mouhamadou Abdoulaye Sonko Abdoul Aziz Wane Raymond Bercion Ousmane Ndiaye Moussa Fafa Cissé Amy Gassama-Sow First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. PLoS ONE |
| title | First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. |
| title_full | First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. |
| title_fullStr | First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. |
| title_full_unstemmed | First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. |
| title_short | First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal. |
| title_sort | first description of the extended spectrum beta lactamase gene blactx m 109 in salmonella grumpensis strains isolated from neonatal nosocomial infections in dakar senegal |
| url | http://europepmc.org/articles/PMC4927072?pdf=render |
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