The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2
The influence of air pollution on human health has sparked widespread concerns across the world. Previously, we found that exposure to ambient fine particulate matter (PM2.5) in our ''real-ambient exposure'' system can result in reduced lung function. However, the mechanism of or...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323002063 |
| _version_ | 1811160854166503424 |
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| author | Jianxin Wang Yongwei Yan Honglin Si Jianyu Li Yanjie Zhao Tianlin Gao Jingbo Pi Rong Zhang Rui Chen Wen Chen Yuxin Zheng Menghui Jiang |
| author_facet | Jianxin Wang Yongwei Yan Honglin Si Jianyu Li Yanjie Zhao Tianlin Gao Jingbo Pi Rong Zhang Rui Chen Wen Chen Yuxin Zheng Menghui Jiang |
| author_sort | Jianxin Wang |
| collection | DOAJ |
| description | The influence of air pollution on human health has sparked widespread concerns across the world. Previously, we found that exposure to ambient fine particulate matter (PM2.5) in our ''real-ambient exposure'' system can result in reduced lung function. However, the mechanism of organ-specific toxicity is still not fully elucidated. The balance of the microbiome contributes to maintaining lung and gut health, but the changes in the microbiome under PM2.5 exposure are not fully understood. Recently, crosstalk between nuclear factor E2-related factor 2 (Nrf2) and the microbiome was reported. However, it is unclear whether Nrf2 affects the lung and gut microbiomes under PM2.5 exposure. In this study, wild-type (WT) and Nrf2-/- (KO) mice were exposed to filtered air (FA) and real ambient PM2.5 (PM) in the '' real-ambient exposure'' system to examine changes in the lung and gut microbiomes. Here, our data suggested microbiome dysbiosis in lung and gut of KO mice under PM2.5 exposure, and Nrf2 ameliorated the microbiome disorder. Our study demonstrated the detrimental impacts of PM2.5 on the lung and gut microbiome by inhaled exposure to air pollution and supported the protective role of Nrf2 in maintaining microbiome homeostasis under PM2.5 exposure. |
| first_indexed | 2024-04-10T06:05:16Z |
| format | Article |
| id | doaj.art-1bee7b387e9945e397a25631e5164d95 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-10T06:05:16Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-1bee7b387e9945e397a25631e5164d952023-03-03T04:23:20ZengElsevierEcotoxicology and Environmental Safety0147-65132023-04-01254114702The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2Jianxin Wang0Yongwei Yan1Honglin Si2Jianyu Li3Yanjie Zhao4Tianlin Gao5Jingbo Pi6Rong Zhang7Rui Chen8Wen Chen9Yuxin Zheng10Menghui Jiang11School of Public Health, Qingdao University, Qingdao, ChinaKey Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Yellow Sea fisheries research institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, China Medical University, Shenyang, ChinaDepartment of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, ChinaSchool of Public Health, Capital Medical University, Beijing, ChinaDepartment of Toxicology, School of Public Health, Sun Yaseen University, Guangzhou, ChinaSchool of Public Health, Qingdao University, Qingdao, ChinaSchool of Public Health, Qingdao University, Qingdao, China; Corresponding author.The influence of air pollution on human health has sparked widespread concerns across the world. Previously, we found that exposure to ambient fine particulate matter (PM2.5) in our ''real-ambient exposure'' system can result in reduced lung function. However, the mechanism of organ-specific toxicity is still not fully elucidated. The balance of the microbiome contributes to maintaining lung and gut health, but the changes in the microbiome under PM2.5 exposure are not fully understood. Recently, crosstalk between nuclear factor E2-related factor 2 (Nrf2) and the microbiome was reported. However, it is unclear whether Nrf2 affects the lung and gut microbiomes under PM2.5 exposure. In this study, wild-type (WT) and Nrf2-/- (KO) mice were exposed to filtered air (FA) and real ambient PM2.5 (PM) in the '' real-ambient exposure'' system to examine changes in the lung and gut microbiomes. Here, our data suggested microbiome dysbiosis in lung and gut of KO mice under PM2.5 exposure, and Nrf2 ameliorated the microbiome disorder. Our study demonstrated the detrimental impacts of PM2.5 on the lung and gut microbiome by inhaled exposure to air pollution and supported the protective role of Nrf2 in maintaining microbiome homeostasis under PM2.5 exposure.http://www.sciencedirect.com/science/article/pii/S0147651323002063LungGutMicrobiomePM2.5Nrf2 |
| spellingShingle | Jianxin Wang Yongwei Yan Honglin Si Jianyu Li Yanjie Zhao Tianlin Gao Jingbo Pi Rong Zhang Rui Chen Wen Chen Yuxin Zheng Menghui Jiang The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 Ecotoxicology and Environmental Safety Lung Gut Microbiome PM2.5 Nrf2 |
| title | The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 |
| title_full | The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 |
| title_fullStr | The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 |
| title_full_unstemmed | The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 |
| title_short | The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2 |
| title_sort | effect of real ambient pm2 5 exposure on the lung and gut microbiomes and the regulation of nrf2 |
| topic | Lung Gut Microbiome PM2.5 Nrf2 |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323002063 |
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